Solubility and Some Crystallization Properties of Conglomerate Forming Chiral Drug Guaifenesin in Water

The solubility of 3-(2-methoxyphenoxy)-propane-1,2-diol, the well-known chiral drug guaifenesin 1, in water has been investigated by means of polythermal and isothermal approaches. It was found that the solubilities of racemic and enantiomeric diols rac- and (R)-1 depend strongly on temperature. The...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2014-10, Vol.103 (10), p.3176-3182
Hauptverfasser:	Fayzullin, Robert R., Lorenz, Heike, Bredikhina, Zemfira A., Bredikhin, Alexander A., Seidel-Morgenstern, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	chirality Crystallization Expectorants - chemistry guaifenesin Guaifenesin - chemistry metastable zone width miscibility gap phase diagram Powder Diffraction preferential crystallization racemic conglomerate separation science Solubility Stereoisomerism Water - chemistry X-ray powder diffractometry
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