MicroRNA-320a inhibits cell proliferation, migration and invasion by targeting BMI-1 in nasopharyngeal carcinoma

•Levels of miR-320a are frequently lower in NPC cell lines and tissues.•Overexpression of miR-320a suppresses NPC cell proliferation in vitro and in vivo.•Overexpression of miR-320a reduces migration and invasion of NPC cells.•miR-320a directly and functionally targets BMI-1.•BMI-1 is up-regulated i...

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Veröffentlicht in:	FEBS letters 2014-10, Vol.588 (20), p.3732-3738
Hauptverfasser:	Qi, Xiaoming, Li, Jianqiang, Zhou, Changbo, Lv, Chunlei, Tian, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals BMI-1 Carcinoma - genetics Carcinoma - metabolism Cell Line, Tumor Cell Movement Cell Proliferation Gene Expression Regulation, Neoplastic Humans Invasion Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism miR-320a Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Neoplasm Invasiveness Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Proliferation Up-Regulation
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