A long-term toxicity test comprising reproduction and growth of zebrafish with 4-chloroaniline
This study describes a long-term test over three generations, using zebrafish (Brachydanio rerio) as the test species and concentrations of 1, 0.2, and 0.04 mg/L 4-chloroaniline (CA) as a model substance. The effect of the compound on the ecologically important parameters reproduction and growth was...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 1990-05, Vol.19 (3), p.419-427 |
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| container_end_page | 427 |
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| container_issue | 3 |
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| container_title | Archives of environmental contamination and toxicology |
| container_volume | 19 |
| creator | BRESCH, H BECK, H EHLERMANN, D SCHLASZUS, H URBANEK, M |
| description | This study describes a long-term test over three generations, using zebrafish (Brachydanio rerio) as the test species and concentrations of 1, 0.2, and 0.04 mg/L 4-chloroaniline (CA) as a model substance. The effect of the compound on the ecologically important parameters reproduction and growth was the focus of interest. Reduction in egg release by fish raised under CA was the most sensitive parameter in the test. Compared to the toxic threshold concentration for growth (0.4 mg/L), egg release was affected by a ten-fold lower concentration (0.04 mg/L). This study demonstrates that a long-term test is still the most appropriate method to assess the chronic toxicity of a substance on fish. A chronic toxicity test is proposed which comprises two generations, with the zebrafish as test species. |
| doi_str_mv | 10.1007/BF01054987 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0090-4341 |
| ispartof | Archives of environmental contamination and toxicology, 1990-05, Vol.19 (3), p.419-427 |
| issn | 0090-4341 1432-0703 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15658362 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aniline Compounds - toxicity Animals Biological and medical sciences Cyprinidae - physiology Environmental pollutants toxicology Freshwater Growth - drug effects Medical sciences Reproduction - drug effects Toxicology Water Zebrafish - physiology |
| title | A long-term toxicity test comprising reproduction and growth of zebrafish with 4-chloroaniline |
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