Effects of ranibizumab on the extracellular matrix production by human Tenon's fibroblast

Anti-Vascular Endothelial Growth Factors (Anti-VEGF) agents have received recent interest as potential anti-fibrotic agents for their concurrent use with trabeculectomy. Preliminary cohort studies have revealed improved bleb morphology following trabeculectomy augmented with ranibizumab. The effects...

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Veröffentlicht in:	Experimental eye research 2014-10, Vol.127, p.236-242
Hauptverfasser:	Md Noh, Siti Munirah, Sheikh Abdul Kadir, Siti H., Bannur, Zakaria M., Froemming, Gabriele Anisah, Abdul Hamid Hasani, Narimah, Mohd Nawawi, Hapizah, Crowston, Jonathan G., Vasudevan, Sushil
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Antibodies, Monoclonal, Humanized - pharmacology Cell Culture Techniques Cell Proliferation - drug effects Cell Survival - drug effects collagen type 1 alpha 1 Collagen Type I - genetics Collagen Type I - metabolism Enzyme-Linked Immunosorbent Assay Fibroblasts - drug effects Fibroblasts - metabolism fibronectin Fibronectins - genetics Fibronectins - metabolism Fluorescent Antibody Technique, Indirect Gene Expression Regulation - physiology Glaucoma, Open-Angle - surgery human Tenon's fibroblast Humans quantitative real time polymerase chain reaction Ranibizumab Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Tenon Capsule - cytology Trabeculectomy Vascular Endothelial Growth Factor A - antagonists & inhibitors Vimentin - metabolism
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