Characterization of full-length recombinant human Proteoglycan 4 as an ocular surface boundary lubricant

Proteoglycan 4 (PRG4, or lubricin) is a lubricating mucin-like glycoprotein recently discovered at the ocular surface, where it functions as a boundary lubricant and appears to play a protective role. Recent technological advances have enabled abundant expression of full-length recombinant human PRG...

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Veröffentlicht in:	Experimental eye research 2014-10, Vol.127, p.14-19
Hauptverfasser:	Samsom, Michael L., Morrison, Sheila, Masala, Nemanja, Sullivan, Benjamin D., Sullivan, David A., Sheardown, Heather, Schmidt, Tannin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Blotting, Western CHO Cells Cornea - drug effects Cricetulus Dimethylpolysiloxanes - pharmacology Electrophoresis, Polyacrylamide Gel Eyelids - drug effects Friction Glycosylation Humans Lubrication lubricin Molecular Weight ocular surface Ophthalmic Solutions - pharmacology Proteoglycans - chemistry Proteoglycans - pharmacology Recombinant Proteins - chemistry Recombinant Proteins - pharmacology rhPRG4 Stress, Physiological - physiology Surface Properties Tandem Mass Spectrometry
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