Synthesis and evaluation of 3-salicyloylpyridine derivatives as cytotoxic mitochondrial apoptosis inducers

A series of 3-salicyloylpyridines were evaluated against human cancer cell line and caused apoptosis in PC-3 cells through loss of membrane potential of mitochondria. A series of novel 3-salicyloylpyridines (4a–h) were synthesized with good yield by modified Knoevenagel–Stobbel method; o-allylation...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-10, Vol.24 (19), p.4724-4728
Hauptverfasser:	Sood, Alisha, Sharma, Vishal, Chaudhry, Ashun, Kumar, Rakesh, Arora, Saroj, Rajnikant, Gupta, Vivek, Ishar, Mohan Paul S.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Formylchromone 3-Salicyloylpyridines Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cytotoxic activity Dose-Response Relationship, Drug Hep G2 Cells Humans MCF-7 Cells Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Models, Molecular Molecular Structure Phenols - chemical synthesis Phenols - chemistry Phenols - pharmacology Phenols - toxicity Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Pyridines - toxicity Reactive Oxygen Species - metabolism Structure-Activity Relationship
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