Effect of γ-cyclodextrin on solubilization and complexation of irbesartan: Influence of pH and excipients

[Display omitted] In effort to prepare an eye drop formulation of irbesartan, the effect of γ-cyclodextrin complexation on irbesartan solubilization in aqueous solutions was investigated. The optimum cyclodextrin concentration for formation of irbesartan/cyclodextrin inclusion complex was found to b...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of pharmaceutics 2014-10, Vol.474 (1-2), p.80-90
Hauptverfasser:	Muankaew, Chutimon, Jansook, Phatsawee, Stefánsson, Einar, Loftsson, Thorsteinn
Format:	Artikel
Sprache:	eng
Schlagworte:	Biphenyl Compounds - chemistry Complexation Excipient Excipients - chemistry gamma-Cyclodextrins - chemistry Hydrogen-Ion Concentration Irbesartan Molecular Structure Solubility Solubilization Tetrazoles - chemistry γ-Cyclodextrin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!