Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with type 2 diabetes
Cerebral small vessel disease, including microvascular lesions, is considered to play an important role in the development of type 2 diabetes mellitus (T2DM)-associated cognitive deficits. With ultra-high field MRI, microvascular lesions (e.g., microinfarcts and microbleeds) can now be visualized in...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2014-10, Vol.63 (10), p.3523-3529 |
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| container_title | Diabetes (New York, N.Y.) |
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| creator | Brundel, Manon Reijmer, Yael D van Veluw, Susanne J Kuijf, Hugo J Luijten, Peter R Kappelle, L Jaap Biessels, Geert Jan |
| description | Cerebral small vessel disease, including microvascular lesions, is considered to play an important role in the development of type 2 diabetes mellitus (T2DM)-associated cognitive deficits. With ultra-high field MRI, microvascular lesions (e.g., microinfarcts and microbleeds) can now be visualized in vivo. For the current study, 48 nondemented older individuals with T2DM (mean age 70.3 ± 4.1 years) and 49 age-, sex-, and education-matched control subjects underwent a 7-Tesla brain MRI scan and a detailed cognitive assessment. The occurrence of cortical microinfarcts and cerebral microbleeds was assessed on fluid-attenuated inversion recovery and T1-weighted and T2*-weighted images, respectively, compared between the groups, and related to cognitive performance. Microinfarcts were found in 38% of control subjects and 48% of patients with T2DM. Microbleeds were present in 41% of control subjects and 33% of patients (all P > 0.05). The presence and number of microinfarcts or microbleeds were unrelated to cognitive performance. This study showed that microvascular brain lesions on ultra-high field MRI are not significantly more common in well-controlled patients with T2DM than in control subjects. |
| doi_str_mv | 10.2337/db14-0122 |
| format | Article |
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With ultra-high field MRI, microvascular lesions (e.g., microinfarcts and microbleeds) can now be visualized in vivo. For the current study, 48 nondemented older individuals with T2DM (mean age 70.3 ± 4.1 years) and 49 age-, sex-, and education-matched control subjects underwent a 7-Tesla brain MRI scan and a detailed cognitive assessment. The occurrence of cortical microinfarcts and cerebral microbleeds was assessed on fluid-attenuated inversion recovery and T1-weighted and T2*-weighted images, respectively, compared between the groups, and related to cognitive performance. Microinfarcts were found in 38% of control subjects and 48% of patients with T2DM. Microbleeds were present in 41% of control subjects and 33% of patients (all P > 0.05). The presence and number of microinfarcts or microbleeds were unrelated to cognitive performance. This study showed that microvascular brain lesions on ultra-high field MRI are not significantly more common in well-controlled patients with T2DM than in control subjects.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db14-0122</identifier><identifier>PMID: 24760137</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Aged ; Aged, 80 and over ; Brain ; Brain - blood supply ; Brain - pathology ; Cerebral Small Vessel Diseases - complications ; Cerebral Small Vessel Diseases - pathology ; Cognition Disorders - etiology ; Cognition Disorders - pathology ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Microvessels - pathology ; NMR ; Nuclear magnetic resonance ; Patients</subject><ispartof>Diabetes (New York, N.Y.), 2014-10, Vol.63 (10), p.3523-3529</ispartof><rights>2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.</rights><rights>Copyright American Diabetes Association Oct 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-2e4de3a869e376281b7a07227677a4f25ebcc1f67d799c0c2e2754e461c021053</citedby><cites>FETCH-LOGICAL-c348t-2e4de3a869e376281b7a07227677a4f25ebcc1f67d799c0c2e2754e461c021053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24760137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brundel, Manon</creatorcontrib><creatorcontrib>Reijmer, Yael D</creatorcontrib><creatorcontrib>van Veluw, Susanne J</creatorcontrib><creatorcontrib>Kuijf, Hugo J</creatorcontrib><creatorcontrib>Luijten, Peter R</creatorcontrib><creatorcontrib>Kappelle, L Jaap</creatorcontrib><creatorcontrib>Biessels, Geert Jan</creatorcontrib><creatorcontrib>Utrecht Vascular Cognitive Impairment Study Group</creatorcontrib><creatorcontrib>on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group</creatorcontrib><title>Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with type 2 diabetes</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>Cerebral small vessel disease, including microvascular lesions, is considered to play an important role in the development of type 2 diabetes mellitus (T2DM)-associated cognitive deficits. With ultra-high field MRI, microvascular lesions (e.g., microinfarcts and microbleeds) can now be visualized in vivo. For the current study, 48 nondemented older individuals with T2DM (mean age 70.3 ± 4.1 years) and 49 age-, sex-, and education-matched control subjects underwent a 7-Tesla brain MRI scan and a detailed cognitive assessment. The occurrence of cortical microinfarcts and cerebral microbleeds was assessed on fluid-attenuated inversion recovery and T1-weighted and T2*-weighted images, respectively, compared between the groups, and related to cognitive performance. Microinfarcts were found in 38% of control subjects and 48% of patients with T2DM. Microbleeds were present in 41% of control subjects and 33% of patients (all P > 0.05). The presence and number of microinfarcts or microbleeds were unrelated to cognitive performance. This study showed that microvascular brain lesions on ultra-high field MRI are not significantly more common in well-controlled patients with T2DM than in control subjects.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain</subject><subject>Brain - blood supply</subject><subject>Brain - pathology</subject><subject>Cerebral Small Vessel Diseases - complications</subject><subject>Cerebral Small Vessel Diseases - pathology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - pathology</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Microvessels - pathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLxDAUhYMozji68A9IwI0uqnm0SbuUwcfAiCAjuDKk6a2ToS-TVpl_b8qoC7mLA4ePw-VD6JSSK8a5vC5yGkeEMraHpjTjWcSZfN1HUxK6iMpMTtCR9xtCiAh3iCYsloJQLqfobQ4OcqcrXFvj2k_tzVBphyvwtm08bhu8tu_ryIFvq6EPHZbRCnyl8ePzAtsGd7q30PQef9l-jfttB5jhwuocevDH6KDUlYeTn5yhl7vb1fwhWj7dL-Y3y8jwOO0jBnEBXKciAy4FS2kuNZGMSSGljkuWQG4MLYUsZJYZYhgwmcQQC2oIoyThM3Sx2-1c-zGA71VtvYGq0g20g1c0EUlCCE_SgJ7_Qzft4JrwnaKCB1mC8ZG63FFBivcOStU5W2u3VZSoUboapatRemDPfhaHvIbij_y1zL8BXn16jg</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Brundel, Manon</creator><creator>Reijmer, Yael D</creator><creator>van Veluw, Susanne J</creator><creator>Kuijf, Hugo J</creator><creator>Luijten, Peter R</creator><creator>Kappelle, L Jaap</creator><creator>Biessels, Geert Jan</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with type 2 diabetes</title><author>Brundel, Manon ; Reijmer, Yael D ; van Veluw, Susanne J ; Kuijf, Hugo J ; Luijten, Peter R ; Kappelle, L Jaap ; Biessels, Geert Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-2e4de3a869e376281b7a07227677a4f25ebcc1f67d799c0c2e2754e461c021053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain</topic><topic>Brain - blood supply</topic><topic>Brain - pathology</topic><topic>Cerebral Small Vessel Diseases - complications</topic><topic>Cerebral Small Vessel Diseases - pathology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - pathology</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Microvessels - pathology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brundel, Manon</creatorcontrib><creatorcontrib>Reijmer, Yael D</creatorcontrib><creatorcontrib>van Veluw, Susanne J</creatorcontrib><creatorcontrib>Kuijf, Hugo J</creatorcontrib><creatorcontrib>Luijten, Peter R</creatorcontrib><creatorcontrib>Kappelle, L Jaap</creatorcontrib><creatorcontrib>Biessels, Geert Jan</creatorcontrib><creatorcontrib>Utrecht Vascular Cognitive Impairment Study Group</creatorcontrib><creatorcontrib>on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brundel, Manon</au><au>Reijmer, Yael D</au><au>van Veluw, Susanne J</au><au>Kuijf, Hugo J</au><au>Luijten, Peter R</au><au>Kappelle, L Jaap</au><au>Biessels, Geert Jan</au><aucorp>Utrecht Vascular Cognitive Impairment Study Group</aucorp><aucorp>on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with type 2 diabetes</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2014-10</date><risdate>2014</risdate><volume>63</volume><issue>10</issue><spage>3523</spage><epage>3529</epage><pages>3523-3529</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>Cerebral small vessel disease, including microvascular lesions, is considered to play an important role in the development of type 2 diabetes mellitus (T2DM)-associated cognitive deficits. With ultra-high field MRI, microvascular lesions (e.g., microinfarcts and microbleeds) can now be visualized in vivo. For the current study, 48 nondemented older individuals with T2DM (mean age 70.3 ± 4.1 years) and 49 age-, sex-, and education-matched control subjects underwent a 7-Tesla brain MRI scan and a detailed cognitive assessment. The occurrence of cortical microinfarcts and cerebral microbleeds was assessed on fluid-attenuated inversion recovery and T1-weighted and T2*-weighted images, respectively, compared between the groups, and related to cognitive performance. Microinfarcts were found in 38% of control subjects and 48% of patients with T2DM. Microbleeds were present in 41% of control subjects and 33% of patients (all P > 0.05). The presence and number of microinfarcts or microbleeds were unrelated to cognitive performance. 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| subjects | Aged Aged, 80 and over Brain Brain - blood supply Brain - pathology Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - pathology Cognition Disorders - etiology Cognition Disorders - pathology Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - pathology Female Humans Magnetic Resonance Imaging Male Microvessels - pathology NMR Nuclear magnetic resonance Patients |
| title | Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with type 2 diabetes |
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