Negative-charge-functionalized mesoporous silica nanoparticles as drug vehicles targeting hepatocellular carcinoma

[Display omitted] In this paper, a series of doxorubicin-loaded and negative-charge-functionalized mesoporous silica nanoparticles (DOX–MSN/COOH) was successfully prepared and used for imaging and targeting therapy of hepatocellular carcinoma. The nanoparticles were uniform and negatively charged, w...

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Veröffentlicht in:	International journal of pharmaceutics 2014-10, Vol.474 (1-2), p.223-231
Hauptverfasser:	Xie, Meng, Xu, Yuanguo, Shen, Haijun, Shen, Song, Ge, Yanru, Xie, Jimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor Biodistribution Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Proliferation - drug effects Cells, Cultured Dose-Response Relationship, Drug Doxorubicin Doxorubicin - administration & dosage Doxorubicin - chemistry Doxorubicin - metabolism Doxorubicin - pharmacokinetics Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Screening Assays, Antitumor Hep G2 Cells Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver tumor in situ Mesoporous silica nanoparticles Mice Mice, Inbred ICR Mice, Nude Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Particle Size Porosity Silicon Dioxide - administration & dosage Silicon Dioxide - chemistry Structure-Activity Relationship Surface Properties Survival rate Tissue Distribution
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