Biological characterization of Campylobacter fetus lipopolysaccharides
Lipopolysaccharides (LPS) of three strains of Campylobacter fetus (subspp. fetus and venerealis, and serotypes A and B), a bacterium of veterinary importance but also a cause of various infections in humans, were assessed for their ability to induce mitogenicity, gelation of Limulus amebocyte lysate...
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| Veröffentlicht in: | FEMS immunology and medical microbiology 1996-08, Vol.15 (1), p.43-50 |
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| container_title | FEMS immunology and medical microbiology |
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| creator | Moran, A.P O'Malley, D.T Vuopio-Varkila, J Varkila, K Pyhala, L Saxen, H Helander, I.M |
| description | Lipopolysaccharides (LPS) of three strains of Campylobacter fetus (subspp. fetus and venerealis, and serotypes A and B), a bacterium of veterinary importance but also a cause of various infections in humans, were assessed for their ability to induce mitogenicity, gelation of Limulus amebocyte lysate, lethal toxicity in mice, and pyrogenicity in rabbits. All C. fetus LPS exhibited activities lower than those of Salmonella typhimurium LPS. LPS of C. fetus subsp. fetus serotype A had the lowest activity in all assays. Since the majority of C. fetus subsp. fetus isolated from humans are serotype A. the lower biological activities of this LPS may aid the pathogenesis of such strains. The lower activities of C. fetus LPS compared with those of S. typhimurium LPS may reflect the presence of longer fatty acid chains in the lipid A of C. fetus LPS. whereas interstrain differences in C. fetus LPS bioactivities may be related to some property influenced by composition of the saccharide moiety. |
| doi_str_mv | 10.1111/j.1574-695X.1996.tb00357.x |
| format | Article |
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All C. fetus LPS exhibited activities lower than those of Salmonella typhimurium LPS. LPS of C. fetus subsp. fetus serotype A had the lowest activity in all assays. Since the majority of C. fetus subsp. fetus isolated from humans are serotype A. the lower biological activities of this LPS may aid the pathogenesis of such strains. The lower activities of C. fetus LPS compared with those of S. typhimurium LPS may reflect the presence of longer fatty acid chains in the lipid A of C. fetus LPS. whereas interstrain differences in C. fetus LPS bioactivities may be related to some property influenced by composition of the saccharide moiety.</description><identifier>ISSN: 0928-8244</identifier><identifier>EISSN: 1574-695X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1111/j.1574-695X.1996.tb00357.x</identifier><identifier>PMID: 8871115</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>amebocyte lysate gelation ; Animals ; B-Lymphocytes - drug effects ; Biocompatibility ; Biological activity ; Campylobacter ; Campylobacter fetus ; Campylobacter fetus - chemistry ; Campylobacter fetus - metabolism ; Campylobacter fetus subsp. fetus ; Campylobacter fetus subsp. venerealis ; Carbohydrates ; characterization ; chemical composition ; Crustaceans ; Endotoxin ; endotoxins ; Endotoxins - toxicity ; Fatty acids ; Fetuses ; Gelation ; genetic variation ; Limulus Test - methods ; Lipid A ; Lipid A - chemistry ; Lipid A - metabolism ; Lipids ; Lipopolysaccharide ; Lipopolysaccharides ; Lipopolysaccharides - analysis ; Lipopolysaccharides - toxicity ; Lymphocyte Activation - drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mitogenicity ; mitogens ; Pathogenesis ; pyrofenicity ; Pyrogenicity ; pyrogens ; Pyrogens - analysis ; Rabbits ; Salmonella ; Salmonella typhimurium ; Serotypes ; Serotyping ; strains ; Toxicity</subject><ispartof>FEMS immunology and medical microbiology, 1996-08, Vol.15 (1), p.43-50</ispartof><rights>1996 Federation of European Microbiological Societies. 1996</rights><rights>1996 Federation of European Microbiological Societies.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3443-fd0d2ef515d460bd36b197dddb46500bdd78daf851566194b803b1bc67fcf32f3</citedby><cites>FETCH-LOGICAL-c3443-fd0d2ef515d460bd36b197dddb46500bdd78daf851566194b803b1bc67fcf32f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-695X.1996.tb00357.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-695X.1996.tb00357.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8871115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moran, A.P</creatorcontrib><creatorcontrib>O'Malley, D.T</creatorcontrib><creatorcontrib>Vuopio-Varkila, J</creatorcontrib><creatorcontrib>Varkila, K</creatorcontrib><creatorcontrib>Pyhala, L</creatorcontrib><creatorcontrib>Saxen, H</creatorcontrib><creatorcontrib>Helander, I.M</creatorcontrib><title>Biological characterization of Campylobacter fetus lipopolysaccharides</title><title>FEMS immunology and medical microbiology</title><addtitle>FEMS Immunol Med Microbiol</addtitle><description>Lipopolysaccharides (LPS) of three strains of Campylobacter fetus (subspp. fetus and venerealis, and serotypes A and B), a bacterium of veterinary importance but also a cause of various infections in humans, were assessed for their ability to induce mitogenicity, gelation of Limulus amebocyte lysate, lethal toxicity in mice, and pyrogenicity in rabbits. All C. fetus LPS exhibited activities lower than those of Salmonella typhimurium LPS. LPS of C. fetus subsp. fetus serotype A had the lowest activity in all assays. Since the majority of C. fetus subsp. fetus isolated from humans are serotype A. the lower biological activities of this LPS may aid the pathogenesis of such strains. The lower activities of C. fetus LPS compared with those of S. typhimurium LPS may reflect the presence of longer fatty acid chains in the lipid A of C. fetus LPS. whereas interstrain differences in C. fetus LPS bioactivities may be related to some property influenced by composition of the saccharide moiety.</description><subject>amebocyte lysate gelation</subject><subject>Animals</subject><subject>B-Lymphocytes - drug effects</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Campylobacter</subject><subject>Campylobacter fetus</subject><subject>Campylobacter fetus - chemistry</subject><subject>Campylobacter fetus - metabolism</subject><subject>Campylobacter fetus subsp. fetus</subject><subject>Campylobacter fetus subsp. venerealis</subject><subject>Carbohydrates</subject><subject>characterization</subject><subject>chemical composition</subject><subject>Crustaceans</subject><subject>Endotoxin</subject><subject>endotoxins</subject><subject>Endotoxins - toxicity</subject><subject>Fatty acids</subject><subject>Fetuses</subject><subject>Gelation</subject><subject>genetic variation</subject><subject>Limulus Test - methods</subject><subject>Lipid A</subject><subject>Lipid A - chemistry</subject><subject>Lipid A - metabolism</subject><subject>Lipids</subject><subject>Lipopolysaccharide</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - analysis</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Mitogenicity</subject><subject>mitogens</subject><subject>Pathogenesis</subject><subject>pyrofenicity</subject><subject>Pyrogenicity</subject><subject>pyrogens</subject><subject>Pyrogens - analysis</subject><subject>Rabbits</subject><subject>Salmonella</subject><subject>Salmonella typhimurium</subject><subject>Serotypes</subject><subject>Serotyping</subject><subject>strains</subject><subject>Toxicity</subject><issn>0928-8244</issn><issn>1574-695X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtv1DAUhS1EVYbCT0BEILFL8DsJEgsYMbRSEQuoxM7ys3jkGad2Ijr8ehwy6gKVRb2xdM_5zr06ALxCsEHlvd02iLW05j370aC-582oICSsbW4fgdWd9BisYI-7usOUPgFPc95CCGkP4Sk47bq2BLEV2Hz0McRrr2Wo9E-ZpB5t8r_l6OO-iq5ay91wCFH9nVfOjlOugh_iEMMhSz0j3tj8DJw4GbJ9fvzPwNXm0_f1eX359fPF-sNlrQmlpHYGGmwdQ8xQDpUhXKG-NcYoyhksA9N2RrquGDhHPVUdJAopzVunHcGOnIE3S-6Q4s1k8yh2PmsbgtzbOGVROIYhbYvx9T_GbZzSvtwmMCEY8h4jWlzvFpdOMedknRiS38l0EAiKuWqxFXOfYu5TzFWLY9XitsAvjismtbPmDj12W_T3i_7LB3t4QLLYXHyhpPBs4eM0_Ieu77_r5cI5GYW8Tj6Lq28YIgIRw7OX_AGIKqh8</recordid><startdate>199608</startdate><enddate>199608</enddate><creator>Moran, A.P</creator><creator>O'Malley, D.T</creator><creator>Vuopio-Varkila, J</creator><creator>Varkila, K</creator><creator>Pyhala, L</creator><creator>Saxen, H</creator><creator>Helander, I.M</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7QL</scope><scope>7U7</scope></search><sort><creationdate>199608</creationdate><title>Biological characterization of Campylobacter fetus lipopolysaccharides</title><author>Moran, A.P ; O'Malley, D.T ; Vuopio-Varkila, J ; Varkila, K ; Pyhala, L ; Saxen, H ; Helander, I.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3443-fd0d2ef515d460bd36b197dddb46500bdd78daf851566194b803b1bc67fcf32f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>amebocyte lysate gelation</topic><topic>Animals</topic><topic>B-Lymphocytes - drug effects</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Campylobacter</topic><topic>Campylobacter fetus</topic><topic>Campylobacter fetus - chemistry</topic><topic>Campylobacter fetus - metabolism</topic><topic>Campylobacter fetus subsp. fetus</topic><topic>Campylobacter fetus subsp. venerealis</topic><topic>Carbohydrates</topic><topic>characterization</topic><topic>chemical composition</topic><topic>Crustaceans</topic><topic>Endotoxin</topic><topic>endotoxins</topic><topic>Endotoxins - toxicity</topic><topic>Fatty acids</topic><topic>Fetuses</topic><topic>Gelation</topic><topic>genetic variation</topic><topic>Limulus Test - methods</topic><topic>Lipid A</topic><topic>Lipid A - chemistry</topic><topic>Lipid A - metabolism</topic><topic>Lipids</topic><topic>Lipopolysaccharide</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - analysis</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Mitogenicity</topic><topic>mitogens</topic><topic>Pathogenesis</topic><topic>pyrofenicity</topic><topic>Pyrogenicity</topic><topic>pyrogens</topic><topic>Pyrogens - analysis</topic><topic>Rabbits</topic><topic>Salmonella</topic><topic>Salmonella typhimurium</topic><topic>Serotypes</topic><topic>Serotyping</topic><topic>strains</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moran, A.P</creatorcontrib><creatorcontrib>O'Malley, D.T</creatorcontrib><creatorcontrib>Vuopio-Varkila, J</creatorcontrib><creatorcontrib>Varkila, K</creatorcontrib><creatorcontrib>Pyhala, L</creatorcontrib><creatorcontrib>Saxen, H</creatorcontrib><creatorcontrib>Helander, I.M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><jtitle>FEMS immunology and medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moran, A.P</au><au>O'Malley, D.T</au><au>Vuopio-Varkila, J</au><au>Varkila, K</au><au>Pyhala, L</au><au>Saxen, H</au><au>Helander, I.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological characterization of Campylobacter fetus lipopolysaccharides</atitle><jtitle>FEMS immunology and medical microbiology</jtitle><addtitle>FEMS Immunol Med Microbiol</addtitle><date>1996-08</date><risdate>1996</risdate><volume>15</volume><issue>1</issue><spage>43</spage><epage>50</epage><pages>43-50</pages><issn>0928-8244</issn><eissn>1574-695X</eissn><eissn>2049-632X</eissn><abstract>Lipopolysaccharides (LPS) of three strains of Campylobacter fetus (subspp. fetus and venerealis, and serotypes A and B), a bacterium of veterinary importance but also a cause of various infections in humans, were assessed for their ability to induce mitogenicity, gelation of Limulus amebocyte lysate, lethal toxicity in mice, and pyrogenicity in rabbits. All C. fetus LPS exhibited activities lower than those of Salmonella typhimurium LPS. LPS of C. fetus subsp. fetus serotype A had the lowest activity in all assays. Since the majority of C. fetus subsp. fetus isolated from humans are serotype A. the lower biological activities of this LPS may aid the pathogenesis of such strains. The lower activities of C. fetus LPS compared with those of S. typhimurium LPS may reflect the presence of longer fatty acid chains in the lipid A of C. fetus LPS. whereas interstrain differences in C. fetus LPS bioactivities may be related to some property influenced by composition of the saccharide moiety.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8871115</pmid><doi>10.1111/j.1574-695X.1996.tb00357.x</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0928-8244 |
| ispartof | FEMS immunology and medical microbiology, 1996-08, Vol.15 (1), p.43-50 |
| issn | 0928-8244 1574-695X 2049-632X |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | amebocyte lysate gelation Animals B-Lymphocytes - drug effects Biocompatibility Biological activity Campylobacter Campylobacter fetus Campylobacter fetus - chemistry Campylobacter fetus - metabolism Campylobacter fetus subsp. fetus Campylobacter fetus subsp. venerealis Carbohydrates characterization chemical composition Crustaceans Endotoxin endotoxins Endotoxins - toxicity Fatty acids Fetuses Gelation genetic variation Limulus Test - methods Lipid A Lipid A - chemistry Lipid A - metabolism Lipids Lipopolysaccharide Lipopolysaccharides Lipopolysaccharides - analysis Lipopolysaccharides - toxicity Lymphocyte Activation - drug effects Mice Mice, Inbred C57BL Mice, Inbred CBA Mitogenicity mitogens Pathogenesis pyrofenicity Pyrogenicity pyrogens Pyrogens - analysis Rabbits Salmonella Salmonella typhimurium Serotypes Serotyping strains Toxicity |
| title | Biological characterization of Campylobacter fetus lipopolysaccharides |
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