New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury
The results of the present study demonstrate that following lethal motor neuron injury microglia and perivascular cells, as well as brain macrophages derived from the latter two cell types, newly express antigens of the myelonocytic lineage as recognized by the monoclonal antibodies ED1 and ED3. It...
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| Veröffentlicht in: | Journal of neuroimmunology 1990-05, Vol.27 (2), p.121-132 |
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| container_end_page | 132 |
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| container_issue | 2 |
| container_start_page | 121 |
| container_title | Journal of neuroimmunology |
| container_volume | 27 |
| creator | Graeber, Manuel B. Streit, Wolfgang J. Kiefer, Reinhard Schoen, Siegfried W. Kreutzberg, Georg W. |
| description | The results of the present study demonstrate that following lethal motor neuron injury microglia and perivascular cells, as well as brain macrophages derived from the latter two cell types, newly express antigens of the myelonocytic lineage as recognized by the monoclonal antibodies ED1 and ED3. It is suggested that differences in the immunophenotype of resident brain macrophage precursor cells, i.e. microglia and perivascular cells, and macrophages occurring outside the central nervous system (CNS) may be explained by differences in local macrophage antigen expression rather than by a different embryological lineage. The new appearance of antigen common to peripheral macrophages on neural phagocytes in CNS lesions may therefore not necessarily imply that most or all of these cells are of recent blood origin. |
| doi_str_mv | 10.1016/0165-5728(90)90061-Q |
| format | Article |
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It is suggested that differences in the immunophenotype of resident brain macrophage precursor cells, i.e. microglia and perivascular cells, and macrophages occurring outside the central nervous system (CNS) may be explained by differences in local macrophage antigen expression rather than by a different embryological lineage. The new appearance of antigen common to peripheral macrophages on neural phagocytes in CNS lesions may therefore not necessarily imply that most or all of these cells are of recent blood origin.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/0165-5728(90)90061-Q</identifier><identifier>PMID: 2332482</identifier><identifier>CODEN: JNRIDW</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adriamycin ; Animals ; Antibodies, Monoclonal ; Antigens - analysis ; Biological and medical sciences ; Blood-Brain Barrier ; Brain - immunology ; Brain macrophage ; Degeneration. Regeneration. Wound healing. Graft ; Doxorubicin - pharmacology ; Fundamental and applied biological sciences. Psychology ; Macrophages - immunology ; Male ; Microglia ; Microscopy, Electron ; Motor neuron degeneration ; Motor Neurons - immunology ; Neuroglia - immunology ; Perivascular cell ; Rats ; Rats, Inbred Strains ; Ricin ; Ricin - pharmacology ; Stem Cells - immunology ; T-Lymphocytes - immunology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of neuroimmunology, 1990-05, Vol.27 (2), p.121-132</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-d42b595e02b9e07c1508e285d066d2c69a6f978b8aa32eb03620f549ec23282f3</citedby><cites>FETCH-LOGICAL-c484t-d42b595e02b9e07c1508e285d066d2c69a6f978b8aa32eb03620f549ec23282f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016557289090061Q$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19591251$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2332482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graeber, Manuel B.</creatorcontrib><creatorcontrib>Streit, Wolfgang J.</creatorcontrib><creatorcontrib>Kiefer, Reinhard</creatorcontrib><creatorcontrib>Schoen, Siegfried W.</creatorcontrib><creatorcontrib>Kreutzberg, Georg W.</creatorcontrib><title>New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>The results of the present study demonstrate that following lethal motor neuron injury microglia and perivascular cells, as well as brain macrophages derived from the latter two cell types, newly express antigens of the myelonocytic lineage as recognized by the monoclonal antibodies ED1 and ED3. It is suggested that differences in the immunophenotype of resident brain macrophage precursor cells, i.e. microglia and perivascular cells, and macrophages occurring outside the central nervous system (CNS) may be explained by differences in local macrophage antigen expression rather than by a different embryological lineage. The new appearance of antigen common to peripheral macrophages on neural phagocytes in CNS lesions may therefore not necessarily imply that most or all of these cells are of recent blood origin.</description><subject>Adriamycin</subject><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Antigens - analysis</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier</subject><subject>Brain - immunology</subject><subject>Brain macrophage</subject><subject>Degeneration. Regeneration. Wound healing. Graft</subject><subject>Doxorubicin - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Microglia</subject><subject>Microscopy, Electron</subject><subject>Motor neuron degeneration</subject><subject>Motor Neurons - immunology</subject><subject>Neuroglia - immunology</subject><subject>Perivascular cell</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Ricin</subject><subject>Ricin - pharmacology</subject><subject>Stem Cells - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJ2G4-_kEDuqSkBzeSbNnSJVBCkwZCy0JzFrI83ijI0layk_rfV9tdklsOg2DmmZfRg9AnSr5SQuvLXLzgDRMXknyRhNS0WH1ASyoaVoiK0QO0fEU-oqOUngihvKzkAi1YWbJKsCWKP-EFw99NhJRs8Dj0eJjBhSH4YObRGqz9aNfgE25nPFgTw9pZnbsd3kC0zzqZyemIDTiXcB-cCy_Wr7GD8VE7PIQxROxhijnc-qcpzifosNcuwen-PUYPN99_X_8o7n_d3l1_uy9MJaqx6CrWcsmBsFYCaQzlRAATvCN13TFTS133shGt0Lpk0JKyZqTnlQTDSiZYXx6jz7vcTQx_JkijGmzanqk9hCkpyuscSZoMVjswfy6lCL3aRDvoOCtK1Fa12npUW49KEvVftVrltbN9_tQO0L0u7d3m-fl-nh1p10ftjU1v2ZJLyjjN3NWOgyzj2UJUyVjwBjobwYyqC_b9Q_4B_K6csA</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Graeber, Manuel B.</creator><creator>Streit, Wolfgang J.</creator><creator>Kiefer, Reinhard</creator><creator>Schoen, Siegfried W.</creator><creator>Kreutzberg, Georg W.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>19900501</creationdate><title>New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury</title><author>Graeber, Manuel B. ; Streit, Wolfgang J. ; Kiefer, Reinhard ; Schoen, Siegfried W. ; Kreutzberg, Georg W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-d42b595e02b9e07c1508e285d066d2c69a6f978b8aa32eb03620f549ec23282f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adriamycin</topic><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Antigens - analysis</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier</topic><topic>Brain - immunology</topic><topic>Brain macrophage</topic><topic>Degeneration. Regeneration. Wound healing. Graft</topic><topic>Doxorubicin - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Microglia</topic><topic>Microscopy, Electron</topic><topic>Motor neuron degeneration</topic><topic>Motor Neurons - immunology</topic><topic>Neuroglia - immunology</topic><topic>Perivascular cell</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Ricin</topic><topic>Ricin - pharmacology</topic><topic>Stem Cells - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graeber, Manuel B.</creatorcontrib><creatorcontrib>Streit, Wolfgang J.</creatorcontrib><creatorcontrib>Kiefer, Reinhard</creatorcontrib><creatorcontrib>Schoen, Siegfried W.</creatorcontrib><creatorcontrib>Kreutzberg, Georg W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graeber, Manuel B.</au><au>Streit, Wolfgang J.</au><au>Kiefer, Reinhard</au><au>Schoen, Siegfried W.</au><au>Kreutzberg, Georg W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>27</volume><issue>2</issue><spage>121</spage><epage>132</epage><pages>121-132</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><coden>JNRIDW</coden><abstract>The results of the present study demonstrate that following lethal motor neuron injury microglia and perivascular cells, as well as brain macrophages derived from the latter two cell types, newly express antigens of the myelonocytic lineage as recognized by the monoclonal antibodies ED1 and ED3. It is suggested that differences in the immunophenotype of resident brain macrophage precursor cells, i.e. microglia and perivascular cells, and macrophages occurring outside the central nervous system (CNS) may be explained by differences in local macrophage antigen expression rather than by a different embryological lineage. The new appearance of antigen common to peripheral macrophages on neural phagocytes in CNS lesions may therefore not necessarily imply that most or all of these cells are of recent blood origin.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2332482</pmid><doi>10.1016/0165-5728(90)90061-Q</doi><tpages>12</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 1990-05, Vol.27 (2), p.121-132 |
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| subjects | Adriamycin Animals Antibodies, Monoclonal Antigens - analysis Biological and medical sciences Blood-Brain Barrier Brain - immunology Brain macrophage Degeneration. Regeneration. Wound healing. Graft Doxorubicin - pharmacology Fundamental and applied biological sciences. Psychology Macrophages - immunology Male Microglia Microscopy, Electron Motor neuron degeneration Motor Neurons - immunology Neuroglia - immunology Perivascular cell Rats Rats, Inbred Strains Ricin Ricin - pharmacology Stem Cells - immunology T-Lymphocytes - immunology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury |
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