Acrolein mutagenicity in the V79 assay
The mutagenicity of acrolein, allyl alcohol, glycidol and propionaldehyde was measured in V79 cells as resistance to 6-thioguanine. Acrolein was tested with and without fetal bovine serum (FBS) (10%; v/v) during the 2 h incubation period. The concentration of FBS did not affect acrolein toxicity but...
Gespeichert in:
| Veröffentlicht in: | Carcinogenesis (New York) 1990-03, Vol.11 (3), p.497-498 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 498 |
|---|---|
| container_issue | 3 |
| container_start_page | 497 |
| container_title | Carcinogenesis (New York) |
| container_volume | 11 |
| creator | Smith, R.A. Cohen, S.M. Lawson, T.A. |
| description | The mutagenicity of acrolein, allyl alcohol, glycidol and propionaldehyde was measured in V79 cells as resistance to 6-thioguanine. Acrolein was tested with and without fetal bovine serum (FBS) (10%; v/v) during the 2 h incubation period. The concentration of FBS did not affect acrolein toxicity but its mutagenicity declined as the concentration of FBS in the medium rose. Allyl alcohol (AA) was as mutagenic as acrolein (ACR). Glycidol was less mutagenic than AA and ACR. Propionaldehyde was not mutagenic at 1 μM; it was toxic at 2 μM. The data suggest that the mutagenicity of these compounds is mediated by their bifunctional nature whereas their cytotoxicity is mediated by the aldehyde function. |
| doi_str_mv | 10.1093/carcin/11.3.497 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15648250</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15648250</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-c63c7dfb1a6177471856176912e0fe541bfc0f75692780c91d37675bb23d12913</originalsourceid><addsrcrecordid>eNpFkMFLwzAUh4Moc07PnoRe3K1bXl-TNMc5dRMGXnSIl5CmqVbbTpMW3H9vpWWe8sLvez8eHyGXQGdAJc6Ndqao5wAznMVSHJExxJyGEST0mIwpxBgiYnxKzrz_oBQ4MjkiowgBQLIxmS6M25W2qIOqbfSbrQtTNPug-zfvNtgKGWjv9f6cnOS69PZieCfk-f7uabkON4-rh-ViExqU0ISGoxFZnoLmIEQsIGHdwCVEluaWxZDmhuaCcRmJhBoJGQouWJpGmEEkASdk2vd-ud13a32jqsIbW5a6trvWK2A8TiJGO3Deg9353jubqy9XVNrtFVD1Z0b1ZhSAQtWZ6Tauhuo2rWx24AcVXX495NobXeZO16bw_7USIeEs6riw5wrf2J9Drt2n4gIFU-uXVwVitRXxza1a4S-Y1XjI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15648250</pqid></control><display><type>article</type><title>Acrolein mutagenicity in the V79 assay</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><creator>Smith, R.A. ; Cohen, S.M. ; Lawson, T.A.</creator><creatorcontrib>Smith, R.A. ; Cohen, S.M. ; Lawson, T.A.</creatorcontrib><description>The mutagenicity of acrolein, allyl alcohol, glycidol and propionaldehyde was measured in V79 cells as resistance to 6-thioguanine. Acrolein was tested with and without fetal bovine serum (FBS) (10%; v/v) during the 2 h incubation period. The concentration of FBS did not affect acrolein toxicity but its mutagenicity declined as the concentration of FBS in the medium rose. Allyl alcohol (AA) was as mutagenic as acrolein (ACR). Glycidol was less mutagenic than AA and ACR. Propionaldehyde was not mutagenic at 1 μM; it was toxic at 2 μM. The data suggest that the mutagenicity of these compounds is mediated by their bifunctional nature whereas their cytotoxicity is mediated by the aldehyde function.</description><identifier>ISSN: 0143-3334</identifier><identifier>EISSN: 1460-2180</identifier><identifier>DOI: 10.1093/carcin/11.3.497</identifier><identifier>PMID: 2311195</identifier><identifier>CODEN: CRNGDP</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>1-Propanol - toxicity ; Acrolein - metabolism ; Acrolein - toxicity ; Aldehydes - toxicity ; Biological and medical sciences ; Chemical mutagenesis ; DNA - metabolism ; Epoxy Compounds - toxicity ; Medical sciences ; Mutagens ; Propanols ; Toxicology</subject><ispartof>Carcinogenesis (New York), 1990-03, Vol.11 (3), p.497-498</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-c63c7dfb1a6177471856176912e0fe541bfc0f75692780c91d37675bb23d12913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19318652$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2311195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, R.A.</creatorcontrib><creatorcontrib>Cohen, S.M.</creatorcontrib><creatorcontrib>Lawson, T.A.</creatorcontrib><title>Acrolein mutagenicity in the V79 assay</title><title>Carcinogenesis (New York)</title><addtitle>Carcinogenesis</addtitle><description>The mutagenicity of acrolein, allyl alcohol, glycidol and propionaldehyde was measured in V79 cells as resistance to 6-thioguanine. Acrolein was tested with and without fetal bovine serum (FBS) (10%; v/v) during the 2 h incubation period. The concentration of FBS did not affect acrolein toxicity but its mutagenicity declined as the concentration of FBS in the medium rose. Allyl alcohol (AA) was as mutagenic as acrolein (ACR). Glycidol was less mutagenic than AA and ACR. Propionaldehyde was not mutagenic at 1 μM; it was toxic at 2 μM. The data suggest that the mutagenicity of these compounds is mediated by their bifunctional nature whereas their cytotoxicity is mediated by the aldehyde function.</description><subject>1-Propanol - toxicity</subject><subject>Acrolein - metabolism</subject><subject>Acrolein - toxicity</subject><subject>Aldehydes - toxicity</subject><subject>Biological and medical sciences</subject><subject>Chemical mutagenesis</subject><subject>DNA - metabolism</subject><subject>Epoxy Compounds - toxicity</subject><subject>Medical sciences</subject><subject>Mutagens</subject><subject>Propanols</subject><subject>Toxicology</subject><issn>0143-3334</issn><issn>1460-2180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUh4Moc07PnoRe3K1bXl-TNMc5dRMGXnSIl5CmqVbbTpMW3H9vpWWe8sLvez8eHyGXQGdAJc6Ndqao5wAznMVSHJExxJyGEST0mIwpxBgiYnxKzrz_oBQ4MjkiowgBQLIxmS6M25W2qIOqbfSbrQtTNPug-zfvNtgKGWjv9f6cnOS69PZieCfk-f7uabkON4-rh-ViExqU0ISGoxFZnoLmIEQsIGHdwCVEluaWxZDmhuaCcRmJhBoJGQouWJpGmEEkASdk2vd-ud13a32jqsIbW5a6trvWK2A8TiJGO3Deg9353jubqy9XVNrtFVD1Z0b1ZhSAQtWZ6Tauhuo2rWx24AcVXX495NobXeZO16bw_7USIeEs6riw5wrf2J9Drt2n4gIFU-uXVwVitRXxza1a4S-Y1XjI</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Smith, R.A.</creator><creator>Cohen, S.M.</creator><creator>Lawson, T.A.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19900301</creationdate><title>Acrolein mutagenicity in the V79 assay</title><author>Smith, R.A. ; Cohen, S.M. ; Lawson, T.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-c63c7dfb1a6177471856176912e0fe541bfc0f75692780c91d37675bb23d12913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>1-Propanol - toxicity</topic><topic>Acrolein - metabolism</topic><topic>Acrolein - toxicity</topic><topic>Aldehydes - toxicity</topic><topic>Biological and medical sciences</topic><topic>Chemical mutagenesis</topic><topic>DNA - metabolism</topic><topic>Epoxy Compounds - toxicity</topic><topic>Medical sciences</topic><topic>Mutagens</topic><topic>Propanols</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, R.A.</creatorcontrib><creatorcontrib>Cohen, S.M.</creatorcontrib><creatorcontrib>Lawson, T.A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Carcinogenesis (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, R.A.</au><au>Cohen, S.M.</au><au>Lawson, T.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acrolein mutagenicity in the V79 assay</atitle><jtitle>Carcinogenesis (New York)</jtitle><addtitle>Carcinogenesis</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>11</volume><issue>3</issue><spage>497</spage><epage>498</epage><pages>497-498</pages><issn>0143-3334</issn><eissn>1460-2180</eissn><coden>CRNGDP</coden><abstract>The mutagenicity of acrolein, allyl alcohol, glycidol and propionaldehyde was measured in V79 cells as resistance to 6-thioguanine. Acrolein was tested with and without fetal bovine serum (FBS) (10%; v/v) during the 2 h incubation period. The concentration of FBS did not affect acrolein toxicity but its mutagenicity declined as the concentration of FBS in the medium rose. Allyl alcohol (AA) was as mutagenic as acrolein (ACR). Glycidol was less mutagenic than AA and ACR. Propionaldehyde was not mutagenic at 1 μM; it was toxic at 2 μM. The data suggest that the mutagenicity of these compounds is mediated by their bifunctional nature whereas their cytotoxicity is mediated by the aldehyde function.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>2311195</pmid><doi>10.1093/carcin/11.3.497</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-3334 |
| ispartof | Carcinogenesis (New York), 1990-03, Vol.11 (3), p.497-498 |
| issn | 0143-3334 1460-2180 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15648250 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | 1-Propanol - toxicity Acrolein - metabolism Acrolein - toxicity Aldehydes - toxicity Biological and medical sciences Chemical mutagenesis DNA - metabolism Epoxy Compounds - toxicity Medical sciences Mutagens Propanols Toxicology |
| title | Acrolein mutagenicity in the V79 assay |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T10%3A31%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acrolein%20mutagenicity%20in%20the%20V79%20assay&rft.jtitle=Carcinogenesis%20(New%20York)&rft.au=Smith,%20R.A.&rft.date=1990-03-01&rft.volume=11&rft.issue=3&rft.spage=497&rft.epage=498&rft.pages=497-498&rft.issn=0143-3334&rft.eissn=1460-2180&rft.coden=CRNGDP&rft_id=info:doi/10.1093/carcin/11.3.497&rft_dat=%3Cproquest_cross%3E15648250%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15648250&rft_id=info:pmid/2311195&rfr_iscdi=true |