Olfactory and hepatic changes following a single inhalation exposure of 3-trifluoromethyl pyridine in rats: concentration and temporal aspects

The effects of a single exposure to 3-trifluoromethyl pyridine (3FMP), were investigated in two studies. In the first study, rats were exposed nose only to 0, 50 or 800 ppm 3FMP for periods of 15 min to 4 h. Half were sacrificed on day 3 and the remainder on day 10. In the second study, rats were ex...

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Veröffentlicht in:	Toxicology (Amsterdam) 1990-05, Vol.62 (1), p.35-51
Hauptverfasser:	Gaskell, Barbara A., Hext, Paul M., Pigott, Geoffrey H., Doe, John E., Hodge, Michael C.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Trifluoromethyl pyridine Administration, Inhalation Animals Biological and medical sciences Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Epithelium - drug effects Epithelium - pathology Inhalation Liver Liver - drug effects Liver - pathology Liver Regeneration - drug effects Male Medical sciences Microscopy - methods Nose Olfactory epithelium Olfactory Mucosa - drug effects Olfactory Mucosa - pathology Pyridines - administration & dosage Pyridines - toxicity Rats Rats, Inbred Strains Staining and Labeling Toxicology Various organic compounds
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