The effect of tamoxifen and two of its non-isomerizable fixed-ring analogs on multistage rat hepatocarcinogenesis

Long-term treatment of breast cancer patients with tamoxifen has prompted concern over potential toxicity of this drug with chronic administration. Since tamoxifen has estrogenic action in the rat liver and estrogenic agents can increase hepatoma incidence in rats, tamoxifen and two non-isomerizable...

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Veröffentlicht in:	Carcinogenesis (New York) 1996-03, Vol.17 (3), p.585-594
Hauptverfasser:	Dragan, Y.P., Fahey, S., Nuwaysir, E., Sattler, C., Babcock, K., Vaughan, J., McCague, R., Jordan, V.C., Pitot, H.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - blood Anticarcinogenic Agents - pharmacokinetics Anticarcinogenic Agents - toxicity Biological and medical sciences Body Weight - drug effects Diethylnitrosamine Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Estrogen Antagonists - blood Estrogen Antagonists - pharmacokinetics Estrogen Antagonists - toxicity Female Liver - drug effects Liver - metabolism Liver - ultrastructure Liver Neoplasms, Experimental - chemically induced Medical sciences Microbodies - drug effects Organ Size - drug effects Pharmacology. Drug treatments Rats Rats, Inbred F344 Tamoxifen - analogs & derivatives Tamoxifen - blood Tamoxifen - pharmacokinetics Tamoxifen - toxicity Toxicity: digestive system Uterus - drug effects
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