Limited Toxicity of Prolonged Therapy with High Doses of Amphotericin B Lipid Complex

We describe six patients with invasive fungal infections who received large cumulative doses (22.3-73.6 g) of amphotericin B lipid complex (ABLC) over 21-121 weeks. The drug was well tolerated at these very large doses, and there was limited toxicity. Collectively, these patients received ABLC thera...

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Veröffentlicht in:	Clinical infectious diseases 1995-11, Vol.21 (5), p.1154-1158
Hauptverfasser:	Kline, Susan, Larsen, Tom A., Fieber, Leonard, Fishbach, Ronald, Greenwood, Martha, Harris, Richard, Kline, Mark W., Tennican, Patrick O., Janoff, Edward N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administered dose Adolescent Adult Amphotericin B - administration & dosage Amphotericin B - adverse effects Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - administration & dosage Antifungal Agents - adverse effects Biological and medical sciences Candidiasis Child Chills Clinical Articles Creatinine - blood Dosage Drug Tolerance Female Fever Fungal infections Humans Hypokalemia - chemically induced Infections Kidney - drug effects Lipids Lipids - administration & dosage Liposomes Male Medical sciences Middle Aged Mycoses - drug therapy Pharmacology. Drug treatments Potassium Potassium - administration & dosage Time Factors
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