Detection of mutation-specific epidermal growth factor receptor (E746–A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma
Abstract The clinical impact of epidermal growth factor receptor (EGFR) (E746–A750del) mutation and human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) is unclear. EGFR (E746–A750del) expression was analyzed in OSCC specimens ( n = 161) by immunohistochemistry. The expression results w...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2014-10, Vol.43 (10), p.1199-1205 |
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| container_title | International journal of oral and maxillofacial surgery |
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| creator | Grimm, M Iftner, T Altaki, H Iftner, A Peters, J.P Munz, A Reinert, S |
| description | Abstract The clinical impact of epidermal growth factor receptor (EGFR) (E746–A750del) mutation and human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) is unclear. EGFR (E746–A750del) expression was analyzed in OSCC specimens ( n = 161) by immunohistochemistry. The expression results were correlated with clinical characteristics and impact on survival. Using INNO-LiPA Extra, high-risk HPV types were genotyped and analyzed in 211 OSCC specimens. Positive EGFR (E746–A750del) expression ( n = 40/161, 25%) was not associated with any clinicopathological characteristics, prognostic factors, social habits (smoking, alcohol consumption), or tumour-specific survival. HPV16 DNA was detected in three out of 211 samples (HPV16-positive: n = 3/211, 1.4%). This study shows that mutation-specific EGFR (E746–A750del) expression and HPV do not appear to be relevant to the survival of patients with OSCC. |
| doi_str_mv | 10.1016/j.ijom.2014.04.006 |
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EGFR (E746–A750del) expression was analyzed in OSCC specimens ( n = 161) by immunohistochemistry. The expression results were correlated with clinical characteristics and impact on survival. Using INNO-LiPA Extra, high-risk HPV types were genotyped and analyzed in 211 OSCC specimens. Positive EGFR (E746–A750del) expression ( n = 40/161, 25%) was not associated with any clinicopathological characteristics, prognostic factors, social habits (smoking, alcohol consumption), or tumour-specific survival. HPV16 DNA was detected in three out of 211 samples (HPV16-positive: n = 3/211, 1.4%). This study shows that mutation-specific EGFR (E746–A750del) expression and HPV do not appear to be relevant to the survival of patients with OSCC.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2014.04.006</identifier><identifier>PMID: 24818747</identifier><language>eng</language><publisher>Denmark: Elsevier Ltd</publisher><subject>Adult ; Aged ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - virology ; Dentistry ; Female ; human papillomavirus ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mouth Neoplasms - genetics ; Mouth Neoplasms - virology ; mutant epidermal growth factor receptor ; Mutation ; oral squamous cell carcinoma ; Papillomaviridae - isolation & purification ; Receptor, Epidermal Growth Factor - genetics ; Retrospective Studies ; Surgery ; Survival Rate</subject><ispartof>International journal of oral and maxillofacial surgery, 2014-10, Vol.43 (10), p.1199-1205</ispartof><rights>International Association of Oral and Maxillofacial Surgeons</rights><rights>2014 International Association of Oral and Maxillofacial Surgeons</rights><rights>Copyright © 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-81b4f2aad74ac8920cfd5f7cc4825a7852e42d0f4d7e791db2cfc1f672498e2b3</citedby><cites>FETCH-LOGICAL-c481t-81b4f2aad74ac8920cfd5f7cc4825a7852e42d0f4d7e791db2cfc1f672498e2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijom.2014.04.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24818747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grimm, M</creatorcontrib><creatorcontrib>Iftner, T</creatorcontrib><creatorcontrib>Altaki, H</creatorcontrib><creatorcontrib>Iftner, A</creatorcontrib><creatorcontrib>Peters, J.P</creatorcontrib><creatorcontrib>Munz, A</creatorcontrib><creatorcontrib>Reinert, S</creatorcontrib><title>Detection of mutation-specific epidermal growth factor receptor (E746–A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma</title><title>International journal of oral and maxillofacial surgery</title><addtitle>Int J Oral Maxillofac Surg</addtitle><description>Abstract The clinical impact of epidermal growth factor receptor (EGFR) (E746–A750del) mutation and human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) is unclear. EGFR (E746–A750del) expression was analyzed in OSCC specimens ( n = 161) by immunohistochemistry. The expression results were correlated with clinical characteristics and impact on survival. Using INNO-LiPA Extra, high-risk HPV types were genotyped and analyzed in 211 OSCC specimens. Positive EGFR (E746–A750del) expression ( n = 40/161, 25%) was not associated with any clinicopathological characteristics, prognostic factors, social habits (smoking, alcohol consumption), or tumour-specific survival. HPV16 DNA was detected in three out of 211 samples (HPV16-positive: n = 3/211, 1.4%). This study shows that mutation-specific EGFR (E746–A750del) expression and HPV do not appear to be relevant to the survival of patients with OSCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Dentistry</subject><subject>Female</subject><subject>human papillomavirus</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - virology</subject><subject>mutant epidermal growth factor receptor</subject><subject>Mutation</subject><subject>oral squamous cell carcinoma</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival Rate</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ustu1TAQtRCIXgo_wAJ5WRa5jB0nTiSEVJXykCqxANaWrz2mvnXi1E6KuuMf2PNxfAmObkGIBdJIHnnOOZqZM4Q8ZbBlwNoX-63fx2HLgYktlID2Htmwuu8rAA73yQZ6YFUDXB6RRznvAaCvO_mQHHHRsU4KuSE_XuOMZvZxpNHRYZn1mld5QuOdNxQnbzENOtAvKX6dL6nTZo6JJjQ4rcnJuRTtz2_fT2UDFsNzqkdLgzZXq579W_xyGfRIJz35EOKgb3xaMvWllIp6vl70EMuHwRCo0cn4sYAekwdOh4xP7t5j8vnN-aezd9XFh7fvz04vKlMmmauO7YTjWlsptOl6DsbZxklTqrzRsms4Cm7BCStR9szuuHGGuVZy0XfId_UxOTnoTileL5hnNfi8tqJHLF0p1rSibnjDRYHyA9SkmHNCp6bkB51uFQO1-qL2avVFrb4oKAFtIT270192A9o_lN9GFMDLAwDLlDcek8rG42jQ-rLqWdno_6__6h-6CX70RocrvMW8j0say_4UU5krUB_Xy1gPgwkoiryufwHzD7cD</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Grimm, M</creator><creator>Iftner, T</creator><creator>Altaki, H</creator><creator>Iftner, A</creator><creator>Peters, J.P</creator><creator>Munz, A</creator><creator>Reinert, S</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Detection of mutation-specific epidermal growth factor receptor (E746–A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma</title><author>Grimm, M ; Iftner, T ; Altaki, H ; Iftner, A ; Peters, J.P ; Munz, A ; Reinert, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-81b4f2aad74ac8920cfd5f7cc4825a7852e42d0f4d7e791db2cfc1f672498e2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Dentistry</topic><topic>Female</topic><topic>human papillomavirus</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - virology</topic><topic>mutant epidermal growth factor receptor</topic><topic>Mutation</topic><topic>oral squamous cell carcinoma</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Receptor, Epidermal Growth Factor - genetics</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grimm, M</creatorcontrib><creatorcontrib>Iftner, T</creatorcontrib><creatorcontrib>Altaki, H</creatorcontrib><creatorcontrib>Iftner, A</creatorcontrib><creatorcontrib>Peters, J.P</creatorcontrib><creatorcontrib>Munz, A</creatorcontrib><creatorcontrib>Reinert, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grimm, M</au><au>Iftner, T</au><au>Altaki, H</au><au>Iftner, A</au><au>Peters, J.P</au><au>Munz, A</au><au>Reinert, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of mutation-specific epidermal growth factor receptor (E746–A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>43</volume><issue>10</issue><spage>1199</spage><epage>1205</epage><pages>1199-1205</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><abstract>Abstract The clinical impact of epidermal growth factor receptor (EGFR) (E746–A750del) mutation and human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) is unclear. EGFR (E746–A750del) expression was analyzed in OSCC specimens ( n = 161) by immunohistochemistry. The expression results were correlated with clinical characteristics and impact on survival. Using INNO-LiPA Extra, high-risk HPV types were genotyped and analyzed in 211 OSCC specimens. Positive EGFR (E746–A750del) expression ( n = 40/161, 25%) was not associated with any clinicopathological characteristics, prognostic factors, social habits (smoking, alcohol consumption), or tumour-specific survival. HPV16 DNA was detected in three out of 211 samples (HPV16-positive: n = 3/211, 1.4%). This study shows that mutation-specific EGFR (E746–A750del) expression and HPV do not appear to be relevant to the survival of patients with OSCC.</abstract><cop>Denmark</cop><pub>Elsevier Ltd</pub><pmid>24818747</pmid><doi>10.1016/j.ijom.2014.04.006</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - virology Dentistry Female human papillomavirus Humans Immunohistochemistry Male Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - virology mutant epidermal growth factor receptor Mutation oral squamous cell carcinoma Papillomaviridae - isolation & purification Receptor, Epidermal Growth Factor - genetics Retrospective Studies Surgery Survival Rate |
| title | Detection of mutation-specific epidermal growth factor receptor (E746–A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma |
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