Azidothymidine in combination with 5-fluorouracil in human colorectal cell lines: In vitro synergistic cytotoxicity and dna-induced strand-breaks

The in vitro cytotoxicity of the combination of azidothymidine (AZT) and 5-fluorouracil (5-FU) against the human colorectal cancer cells SW-480, SW-620 and COLO-320DM was evaluated. The cytotoxic effects of 5-FU and AZT were determined by the assay using 2,3-bis(2-methoxy-4-nitro-5-sulfophenil)- 2H-...

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Veröffentlicht in:	European journal of cancer (1990) 1996-06, Vol.32 (7), p.1219-1226
Hauptverfasser:	Andreuccetti, M., Allegrini, G., Antonuzzo, A., Malvaldi, G., Conte, P.F., Danesi, R., Del Tacca, M., Falcone, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology azidothymidine Biological and medical sciences Cell Death - drug effects color ectal cancer cell lines Colorectal Neoplasms - pathology DNA Damage DNA strand-breaks DNA, Neoplasm - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Drug Synergism Fluorouracil - pharmacology General aspects Humans Medical sciences Pharmacology. Drug treatments synergistic cytotoxicity Tumor Cells, Cultured - drug effects Zidovudine - pharmacology
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