Analysis of the response of human keratinocytes to Malassezia globosa and restricta strains
Malassezia spp. are saprophyte yeasts involved in skin diseases with different degrees of severity. The aim of our study was to analyze the response of human epidermal keratinocytes to Malassezia globosa and restricta strains evaluating the host defence mechanisms induced by Malassezia spp. coloniza...
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| Veröffentlicht in: | Archives of Dermatological Research 2014-10, Vol.306 (8), p.763-768 |
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| creator | Donnarumma, Giovanna Perfetto, Brunella Paoletti, Iole Oliviero, Giovanni Clavaud, Cécile Del Bufalo, Aurelia Guéniche, Audrey Jourdain, Roland Tufano, Maria Antonietta Breton, Lionel |
| description | Malassezia
spp. are saprophyte yeasts involved in skin diseases with different degrees of severity. The aim of our study was to analyze the response of human epidermal keratinocytes to
Malassezia globosa
and
restricta
strains evaluating the host defence mechanisms induced by
Malassezia
spp. colonization. Our results showed a different modulation of the inflammatory and immunomodulatory cytokine pathways obtained with the different strains of
Malassezia
tested. In addition, this expression is altered by blocking the TLR2 receptor. In comparison with
M. furfur
,
M. globosa
and
restricta
displayed an unexpected and striking cytotoxicity on keratinocytes. The differences observed could be related to the different modalities of interaction between keratinocytes and
Malassezia
strains, but also to their growth condition. Taken together, these results indicate that
M. globosa
or
M. restricta
colonization exert a different control on the cytokine inflammatory response activated in the human keratinocyte in which TLR2 might be involved.
M. globosa
and
M. restricta
may play a synergistic role in the exacerbation of skin diseases in which both are found. |
| doi_str_mv | 10.1007/s00403-014-1479-1 |
| format | Article |
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spp. are saprophyte yeasts involved in skin diseases with different degrees of severity. The aim of our study was to analyze the response of human epidermal keratinocytes to
Malassezia globosa
and
restricta
strains evaluating the host defence mechanisms induced by
Malassezia
spp. colonization. Our results showed a different modulation of the inflammatory and immunomodulatory cytokine pathways obtained with the different strains of
Malassezia
tested. In addition, this expression is altered by blocking the TLR2 receptor. In comparison with
M. furfur
,
M. globosa
and
restricta
displayed an unexpected and striking cytotoxicity on keratinocytes. The differences observed could be related to the different modalities of interaction between keratinocytes and
Malassezia
strains, but also to their growth condition. Taken together, these results indicate that
M. globosa
or
M. restricta
colonization exert a different control on the cytokine inflammatory response activated in the human keratinocyte in which TLR2 might be involved.
M. globosa
and
M. restricta
may play a synergistic role in the exacerbation of skin diseases in which both are found.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-014-1479-1</identifier><identifier>PMID: 25038621</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Apoptosis ; Cells, Cultured ; Concise Communication ; Cytokines - metabolism ; Dermatology ; Dermatomycoses - immunology ; Dermatomycoses - microbiology ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators - immunology ; Keratinocytes - immunology ; Keratinocytes - microbiology ; Malassezia - growth & development ; Medicine ; Medicine & Public Health ; Toll-Like Receptor 2 - immunology</subject><ispartof>Archives of Dermatological Research, 2014-10, Vol.306 (8), p.763-768</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-619935abd43474eed87c013ab94c13d6b60f178ef90ebce128995606ba07748b3</citedby><cites>FETCH-LOGICAL-c438t-619935abd43474eed87c013ab94c13d6b60f178ef90ebce128995606ba07748b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-014-1479-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-014-1479-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25038621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donnarumma, Giovanna</creatorcontrib><creatorcontrib>Perfetto, Brunella</creatorcontrib><creatorcontrib>Paoletti, Iole</creatorcontrib><creatorcontrib>Oliviero, Giovanni</creatorcontrib><creatorcontrib>Clavaud, Cécile</creatorcontrib><creatorcontrib>Del Bufalo, Aurelia</creatorcontrib><creatorcontrib>Guéniche, Audrey</creatorcontrib><creatorcontrib>Jourdain, Roland</creatorcontrib><creatorcontrib>Tufano, Maria Antonietta</creatorcontrib><creatorcontrib>Breton, Lionel</creatorcontrib><title>Analysis of the response of human keratinocytes to Malassezia globosa and restricta strains</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>Malassezia
spp. are saprophyte yeasts involved in skin diseases with different degrees of severity. The aim of our study was to analyze the response of human epidermal keratinocytes to
Malassezia globosa
and
restricta
strains evaluating the host defence mechanisms induced by
Malassezia
spp. colonization. Our results showed a different modulation of the inflammatory and immunomodulatory cytokine pathways obtained with the different strains of
Malassezia
tested. In addition, this expression is altered by blocking the TLR2 receptor. In comparison with
M. furfur
,
M. globosa
and
restricta
displayed an unexpected and striking cytotoxicity on keratinocytes. The differences observed could be related to the different modalities of interaction between keratinocytes and
Malassezia
strains, but also to their growth condition. Taken together, these results indicate that
M. globosa
or
M. restricta
colonization exert a different control on the cytokine inflammatory response activated in the human keratinocyte in which TLR2 might be involved.
M. globosa
and
M. restricta
may play a synergistic role in the exacerbation of skin diseases in which both are found.</description><subject>Apoptosis</subject><subject>Cells, Cultured</subject><subject>Concise Communication</subject><subject>Cytokines - metabolism</subject><subject>Dermatology</subject><subject>Dermatomycoses - immunology</subject><subject>Dermatomycoses - microbiology</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Inflammation Mediators - immunology</subject><subject>Keratinocytes - immunology</subject><subject>Keratinocytes - microbiology</subject><subject>Malassezia - growth & development</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Toll-Like Receptor 2 - immunology</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LxDAQhoMouqg_wIsEvHipTpps0hxF_ALFi4LgIaTtVKvdZs20h_XXm3VVRDCXIeR53wkPY3sCjgSAOSYABTIDoTKhjM3EGpsIJfMMtH1YZxOQCjKprd5iu0QvkI4BlYPZZFv5FGShczFhjye97xbUEg8NH56RR6R56AmX9-dx5nv-itEPbR-qxYDEh8BvfOeJ8L31_KkLZSDPfV8vk0Nsq8HzNH3b0w7baHxHuPs1t9n9-dnd6WV2fXtxdXpynVVKFkOmhbVy6staSWUUYl2YCoT0pVWVkLUuNTTCFNhYwLJCkRfWTjXo0oMxqijlNjtc9c5jeBvTL9yspQq7zvcYRnJiqqW1SY1O6MEf9CWMMSn4pHJrrSnyRIkVVcVAFLFx89jOfFw4AW4p363kuyTfLeU7kTL7X81jOcP6J_GtOgH5CqD01D9h_LX639YPbb2Oig</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Donnarumma, Giovanna</creator><creator>Perfetto, Brunella</creator><creator>Paoletti, Iole</creator><creator>Oliviero, Giovanni</creator><creator>Clavaud, Cécile</creator><creator>Del Bufalo, Aurelia</creator><creator>Guéniche, Audrey</creator><creator>Jourdain, Roland</creator><creator>Tufano, Maria Antonietta</creator><creator>Breton, Lionel</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Analysis of the response of human keratinocytes to Malassezia globosa and restricta strains</title><author>Donnarumma, Giovanna ; Perfetto, Brunella ; Paoletti, Iole ; Oliviero, Giovanni ; Clavaud, Cécile ; Del Bufalo, Aurelia ; Guéniche, Audrey ; Jourdain, Roland ; Tufano, Maria Antonietta ; Breton, Lionel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-619935abd43474eed87c013ab94c13d6b60f178ef90ebce128995606ba07748b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Apoptosis</topic><topic>Cells, Cultured</topic><topic>Concise Communication</topic><topic>Cytokines - metabolism</topic><topic>Dermatology</topic><topic>Dermatomycoses - immunology</topic><topic>Dermatomycoses - microbiology</topic><topic>Host-Pathogen Interactions</topic><topic>Humans</topic><topic>Inflammation Mediators - immunology</topic><topic>Keratinocytes - immunology</topic><topic>Keratinocytes - microbiology</topic><topic>Malassezia - growth & development</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Toll-Like Receptor 2 - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donnarumma, Giovanna</creatorcontrib><creatorcontrib>Perfetto, Brunella</creatorcontrib><creatorcontrib>Paoletti, Iole</creatorcontrib><creatorcontrib>Oliviero, Giovanni</creatorcontrib><creatorcontrib>Clavaud, Cécile</creatorcontrib><creatorcontrib>Del Bufalo, Aurelia</creatorcontrib><creatorcontrib>Guéniche, Audrey</creatorcontrib><creatorcontrib>Jourdain, Roland</creatorcontrib><creatorcontrib>Tufano, Maria Antonietta</creatorcontrib><creatorcontrib>Breton, Lionel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donnarumma, Giovanna</au><au>Perfetto, Brunella</au><au>Paoletti, Iole</au><au>Oliviero, Giovanni</au><au>Clavaud, Cécile</au><au>Del Bufalo, Aurelia</au><au>Guéniche, Audrey</au><au>Jourdain, Roland</au><au>Tufano, Maria Antonietta</au><au>Breton, Lionel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the response of human keratinocytes to Malassezia globosa and restricta strains</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>306</volume><issue>8</issue><spage>763</spage><epage>768</epage><pages>763-768</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Malassezia
spp. are saprophyte yeasts involved in skin diseases with different degrees of severity. The aim of our study was to analyze the response of human epidermal keratinocytes to
Malassezia globosa
and
restricta
strains evaluating the host defence mechanisms induced by
Malassezia
spp. colonization. Our results showed a different modulation of the inflammatory and immunomodulatory cytokine pathways obtained with the different strains of
Malassezia
tested. In addition, this expression is altered by blocking the TLR2 receptor. In comparison with
M. furfur
,
M. globosa
and
restricta
displayed an unexpected and striking cytotoxicity on keratinocytes. The differences observed could be related to the different modalities of interaction between keratinocytes and
Malassezia
strains, but also to their growth condition. Taken together, these results indicate that
M. globosa
or
M. restricta
colonization exert a different control on the cytokine inflammatory response activated in the human keratinocyte in which TLR2 might be involved.
M. globosa
and
M. restricta
may play a synergistic role in the exacerbation of skin diseases in which both are found.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25038621</pmid><doi>10.1007/s00403-014-1479-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-3696 |
| ispartof | Archives of Dermatological Research, 2014-10, Vol.306 (8), p.763-768 |
| issn | 0340-3696 1432-069X |
| language | eng |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Apoptosis Cells, Cultured Concise Communication Cytokines - metabolism Dermatology Dermatomycoses - immunology Dermatomycoses - microbiology Host-Pathogen Interactions Humans Inflammation Mediators - immunology Keratinocytes - immunology Keratinocytes - microbiology Malassezia - growth & development Medicine Medicine & Public Health Toll-Like Receptor 2 - immunology |
| title | Analysis of the response of human keratinocytes to Malassezia globosa and restricta strains |
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