Repression of contexual fear memory induced by isoflurane is accompanied by reduction in histone acetylation and rescued by sodium butyrate

Isoflurane produces amnesia in mice during contextual fear conditioning (CFC) trials. Histone acetylation is a form of chromatin modification involved in the transcriptional regulation underlying memory formation. We investigated whether isoflurane-induced repression of contextual fear memory is rel...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2014-10, Vol.113 (4), p.634-643
Hauptverfasser:	Zhong, T., Qing, Q.J., Yang, Y., Zou, W.Y., Ye, Z., Yan, J.Q., Guo, Q.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation amnesia anaesthetics volatile, isoflurane Anesthetics, Inhalation - pharmacology Animals Behavior, Animal - drug effects Blotting, Western Brain Chemistry - drug effects Butyric Acid - pharmacology Conditioning (Psychology) - drug effects Epigenesis, Genetic - drug effects epigenetics, acetylation Fear - drug effects Gene Expression - drug effects hippocampus Hippocampus - drug effects Hippocampus - metabolism Histone Deacetylase Inhibitors - pharmacology Histones - metabolism Immunohistochemistry Isoflurane - pharmacology Male Memory - drug effects Memory - physiology Mice Mice, Inbred C57BL proto-oncogene proteins c-Fos Proto-Oncogene Proteins c-fos - biosynthesis sodium butyrate
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