Duhuo Jisheng Decoction-containing serum promotes proliferation of interleukin-1β-induced chondrocytes through the p16-cyclin D1/CDK4-Rb pathway

Duhuo Jisheng Decoction (DHJSD) is a traditional Chinese herbal medicine that has multiple uses, including as a treatment for osteoarthritis (OA). However, the molecular mechanisms underlying the therapeutic effects of DHJSD on OA remain unknown. In the present study, a serum pharmacological method...

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Veröffentlicht in:	Molecular medicine reports 2014-11, Vol.10 (5), p.2525-2534
Hauptverfasser:	WU, GUANGWEN, FAN, HUAILING, HUANG, YUANPENG, ZHENG, CHUNSONG, YE, JINXIA, LIU, XIANXIANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Arthritis Cancer Care and treatment Cell culture Cell cycle Cell proliferation Cell Proliferation - drug effects Cell Survival Cells, Cultured Chinese medicine Chondrocytes Chondrocytes - drug effects Chondrocytes - physiology Cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-dependent kinase 4 Cyclin-Dependent Kinase 4 - genetics Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Drug dosages Drugs, Chinese Herbal - pharmacology Duhuo Jisheng Decoction Female Flow cytometry Gene expression Gene Expression - drug effects Health aspects Herbal medicine IL-1β IL-1β-induced chondrocyte Interleukin-1beta - physiology Interleukins Kinases Laboratory animals Male Medicine, Chinese Molecular modelling Osteoarthritis Phase transitions Polymerase chain reaction proliferation Protein expression Rats, Sprague-Dawley Retina Retinoblastoma Retinoblastoma protein Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism Reverse transcription Rodents S phase Signal Transduction - drug effects Studies Tumor suppressor genes Western blotting
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