Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis

In obesity, a paracrine loop between adipocytes and macrophages augments chronic inflammation of adipose tissue, thereby inducing systemic insulin resistance and ectopic lipid accumulation. Obese adipose tissue contains a unique histological structure termed crown-like structure (CLS), where adipocy...

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Veröffentlicht in:	Nature communications 2014-09, Vol.5 (1), p.4982-4982, Article 4982
Hauptverfasser:	Tanaka, Miyako, Ikeda, Kenji, Suganami, Takayoshi, Komiya, Chikara, Ochi, Kozue, Shirakawa, Ibuki, Hamaguchi, Miho, Nishimura, Satoshi, Manabe, Ichiro, Matsuda, Takahisa, Kimura, Kumi, Inoue, Hiroshi, Inagaki, Yutaka, Aoe, Seiichiro, Yamasaki, Sho, Ogawa, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2504/342 692/420 692/699/2743/393 Adipocytes - cytology Adipose tissue Adipose Tissue - metabolism Adipose Tissue - physiopathology Animals Body fat Fibrosis Humanities and Social Sciences Inflammation - metabolism Insulin Resistance Lectins, C-Type - metabolism Ligands Lipids - chemistry Liver - metabolism Macrophages - cytology Macrophages - metabolism Male Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary Obesity Obesity - metabolism Receptors, Cell Surface - metabolism RNA, Messenger - metabolism Science Science (multidisciplinary)
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