Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells

Interleukin-1β (IL-1β) is a pleiotropic cytokine that mediates inflammatory and cell death activities. IL-1β has been previously reported to induce apoptosis of intervertebral disc (IVD) cells in IVD degeneration. Accumulating data have suggested that post-menopausal women have a high incidence of I...

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Veröffentlicht in:	Molecular medicine reports 2014-11, Vol.10 (5), p.2745-2751
Hauptverfasser:	WANG, HAIYING, DING, WENYUAN, YANG, DALONG, GU, TIXIN, YANG, SIDONG, BAI, ZHILONG
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Annexin V annulus fibrosus cells Apoptosis Back pain Caspase Caspase 3 - metabolism Caspase-3 Cell cycle Cell death Cell growth Cell Survival Cells, Cultured Cytokines Degeneration dose-dependent manner Dose-response relationship (Biochemistry) Dose-Response Relationship, Drug Enzymes Estradiol Estradiol - pharmacology Estradiol - physiology Estrogens Females Genetic aspects IL-1β Inflammation Interleukin-1beta - physiology Interleukin-1β Intervertebral Disc - cytology Laboratory animals Male Males Pharmacology, Experimental Phenols Properties Propidium iodide Rats, Sprague-Dawley Rodents Studies Tumor necrosis factor-TNF
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