Antithrombin-resistant prothrombin Yukuhashi mutation also causes thrombomodulin resistance in fibrinogen clotting but not in protein C activation

Abstract Introduction Prothrombin Yukuhashi (p.Arg596Leu) mutation can result in thrombophilia associated with antithrombin (AT) resistance. Mutant thrombin, an active form of prothrombin Yukuhashi, demonstrated moderately lower clotting activity than the wild-type but substantially impaired the for...

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Veröffentlicht in:	Thrombosis research 2014-10, Vol.134 (4), p.914-917
Hauptverfasser:	Takagi, Yuki, Kato, Io, Ando, Yumi, Nakamura, Yuki, Murata, Moe, Takagi, Akira, Murate, Takashi, Kojima, Tetsuhito
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombin Proteins - metabolism antithrombin resistance Blood Coagulation Tests Enzyme Activation fibrinogen Fibrinogen - metabolism Hematology, Oncology and Palliative Medicine Humans Mutation protein C Protein C - metabolism Prothrombin - genetics Prothrombin - metabolism prothrombin Yukuhashi Recombinant Proteins - genetics Recombinant Proteins - metabolism thrombomodulin Thrombomodulin - metabolism
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