Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hema...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2014-09, Vol.345 (6203), p.1509-1512 |
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| creator | Fares, Iman Chagraoui, Jalila Gareau, Yves Gingras, Stéphane Ruel, Réjean Mayotte, Nadine Csaszar, Elizabeth Knapp, David J H F Miller, Paul Ngom, Mor Imren, Suzan Roy, Denis-Claude Watts, Kori L Kiem, Hans-Peter Herrington, Robert Iscove, Norman N Humphries, R Keith Eaves, Connie J Cohen, Sandra Marinier, Anne Zandstra, Peter W Sauvageau, Guy |
| description | The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy. |
| doi_str_mv | 10.1126/science.1256337 |
| format | Article |
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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Fares, Iman ; Chagraoui, Jalila ; Gareau, Yves ; Gingras, Stéphane ; Ruel, Réjean ; Mayotte, Nadine ; Csaszar, Elizabeth ; Knapp, David J H F ; Miller, Paul ; Ngom, Mor ; Imren, Suzan ; Roy, Denis-Claude ; Watts, Kori L ; Kiem, Hans-Peter ; Herrington, Robert ; Iscove, Norman N ; Humphries, R Keith ; Eaves, Connie J ; Cohen, Sandra ; Marinier, Anne ; Zandstra, Peter W ; Sauvageau, Guy</creator><creatorcontrib>Fares, Iman ; Chagraoui, Jalila ; Gareau, Yves ; Gingras, Stéphane ; Ruel, Réjean ; Mayotte, Nadine ; Csaszar, Elizabeth ; Knapp, David J H F ; Miller, Paul ; Ngom, Mor ; Imren, Suzan ; Roy, Denis-Claude ; Watts, Kori L ; Kiem, Hans-Peter ; Herrington, Robert ; Iscove, Norman N ; Humphries, R Keith ; Eaves, Connie J ; Cohen, Sandra ; Marinier, Anne ; Zandstra, Peter W ; Sauvageau, Guy</creatorcontrib><description>The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. 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| identifier | EISSN: 1095-9203 |
| ispartof | Science (American Association for the Advancement of Science), 2014-09, Vol.345 (6203), p.1509-1512 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Animals Cell Culture Techniques Fetal Blood - cytology Fetal Blood - drug effects Fetal Blood - physiology Genetic Therapy - methods Hematopoiesis - drug effects Hematopoiesis - physiology Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Humans Immunocompromised Host Indoles - chemistry Indoles - pharmacology Mice Pyrimidines - chemistry Pyrimidines - pharmacology Receptors, Aryl Hydrocarbon - antagonists & inhibitors Regeneration - drug effects Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology |
| title | Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal |
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