The pathogenesis of Achilles tendinopathy: A systematic review
Abstract Achilles tendinopathy is a degenerative, not an inflammatory, condition. It is prevalent in athletes involved in running sports. A systematic literature review on Achilles tendon tendinopathy has been performed according to the intrinsic (age, sex, body weight, tendon temperature, systemic...
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| Veröffentlicht in: | Foot and ankle surgery 2014-09, Vol.20 (3), p.154-159 |
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| creator | Magnan, Bruno, MD Bondi, Manuel, MD Pierantoni, Silvia, MD Samaila, Elena, MD |
| description | Abstract Achilles tendinopathy is a degenerative, not an inflammatory, condition. It is prevalent in athletes involved in running sports. A systematic literature review on Achilles tendon tendinopathy has been performed according to the intrinsic (age, sex, body weight, tendon temperature, systemic diseases, muscle strength, flexibility, previous injuries and anatomical variants, genetic predisposition and blood supply) and extrinsic risk factors (drugs and overuse), which can cause tendon suffering and degeneration. Different theories have been found: Neurogenic, Angiogenic, Impingement and “Iceberg” Hypotheses. Multiple databases were utilized for articles published between 1964 and 2013. The different hypothesis were analyzed, differently considering those concerning the pathogenesis of tendinopathy and those concerning the etiology of complaints in patients. This review of the literature demonstrates the heterogeneity of Achilles tendinopathy pathogenesis. Various risk factors have been identified and have shown an interaction between them such as genes, age, circulating and local cytokine production, sex, biomechanics and body composition. |
| doi_str_mv | 10.1016/j.fas.2014.02.010 |
| format | Article |
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It is prevalent in athletes involved in running sports. A systematic literature review on Achilles tendon tendinopathy has been performed according to the intrinsic (age, sex, body weight, tendon temperature, systemic diseases, muscle strength, flexibility, previous injuries and anatomical variants, genetic predisposition and blood supply) and extrinsic risk factors (drugs and overuse), which can cause tendon suffering and degeneration. Different theories have been found: Neurogenic, Angiogenic, Impingement and “Iceberg” Hypotheses. Multiple databases were utilized for articles published between 1964 and 2013. The different hypothesis were analyzed, differently considering those concerning the pathogenesis of tendinopathy and those concerning the etiology of complaints in patients. This review of the literature demonstrates the heterogeneity of Achilles tendinopathy pathogenesis. Various risk factors have been identified and have shown an interaction between them such as genes, age, circulating and local cytokine production, sex, biomechanics and body composition.</description><identifier>ISSN: 1268-7731</identifier><identifier>EISSN: 1460-9584</identifier><identifier>DOI: 10.1016/j.fas.2014.02.010</identifier><identifier>PMID: 25103700</identifier><language>eng</language><publisher>France: Elsevier Ltd</publisher><subject>Achilles pathogenesis ; Achilles tendinopathy ; Achilles Tendon ; Humans ; Orthopedics ; Risk Factors ; Tendinopathy - etiology ; Tendinopathy - therapy ; Tendon degeneration</subject><ispartof>Foot and ankle surgery, 2014-09, Vol.20 (3), p.154-159</ispartof><rights>European Foot and Ankle Society</rights><rights>2014 European Foot and Ankle Society</rights><rights>Copyright © 2014 European Foot and Ankle Society. Published by Elsevier Ltd. 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Various risk factors have been identified and have shown an interaction between them such as genes, age, circulating and local cytokine production, sex, biomechanics and body composition.</description><subject>Achilles pathogenesis</subject><subject>Achilles tendinopathy</subject><subject>Achilles Tendon</subject><subject>Humans</subject><subject>Orthopedics</subject><subject>Risk Factors</subject><subject>Tendinopathy - etiology</subject><subject>Tendinopathy - therapy</subject><subject>Tendon degeneration</subject><issn>1268-7731</issn><issn>1460-9584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EoqXwA7igHLkkzNiOkwWp0qrio1IlDm0lbpZjT1gv2WTxZEH773G0hUMPnDySn3ekeV4hXiNUCGjebavecSUBdQWyAoQn4hy1gXJVt_ppnqVpy6ZReCZeMG8BoFmBei7OZI2gGoBzcXm3oWLv5s30nUbiyMXUF2u_icNAXMw0hjhOy__xfbEu-Mgz7dwcfZHoV6TfL8Wz3g1Mrx7eC3H_6ePd1Zfy5uvn66v1TelrreeyleS17JxXHlTnVloH6U1LTei9g67vZADEvnd1pnRoMmOwM6YO3gSNrboQb09792n6eSCe7S6yp2FwI00HtlgbtWoVqiajeEJ9mpgT9Xaf4s6lo0Wwiza7tVmbXbRZkDZry5k3D-sP3Y7Cv8RfTxn4cAIoH5kPT5Z9pNFTiIn8bMMU_7v-8lHaD3GM3g0_6Ei8nQ5pzPYsWs4Be7v0ttSGOlemmm_qD6z6kl0</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Magnan, Bruno, MD</creator><creator>Bondi, Manuel, MD</creator><creator>Pierantoni, Silvia, MD</creator><creator>Samaila, Elena, MD</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>The pathogenesis of Achilles tendinopathy: A systematic review</title><author>Magnan, Bruno, MD ; Bondi, Manuel, MD ; Pierantoni, Silvia, MD ; Samaila, Elena, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-82ec42bac3c03ba944d2c68e7dfca0bfb2d011ffa542b4d73ba61b665dc6d4183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Achilles pathogenesis</topic><topic>Achilles tendinopathy</topic><topic>Achilles Tendon</topic><topic>Humans</topic><topic>Orthopedics</topic><topic>Risk Factors</topic><topic>Tendinopathy - etiology</topic><topic>Tendinopathy - therapy</topic><topic>Tendon degeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magnan, Bruno, MD</creatorcontrib><creatorcontrib>Bondi, Manuel, MD</creatorcontrib><creatorcontrib>Pierantoni, Silvia, MD</creatorcontrib><creatorcontrib>Samaila, Elena, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Foot and ankle surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magnan, Bruno, MD</au><au>Bondi, Manuel, MD</au><au>Pierantoni, Silvia, MD</au><au>Samaila, Elena, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pathogenesis of Achilles tendinopathy: A systematic review</atitle><jtitle>Foot and ankle surgery</jtitle><addtitle>Foot Ankle Surg</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>20</volume><issue>3</issue><spage>154</spage><epage>159</epage><pages>154-159</pages><issn>1268-7731</issn><eissn>1460-9584</eissn><abstract>Abstract Achilles tendinopathy is a degenerative, not an inflammatory, condition. It is prevalent in athletes involved in running sports. A systematic literature review on Achilles tendon tendinopathy has been performed according to the intrinsic (age, sex, body weight, tendon temperature, systemic diseases, muscle strength, flexibility, previous injuries and anatomical variants, genetic predisposition and blood supply) and extrinsic risk factors (drugs and overuse), which can cause tendon suffering and degeneration. Different theories have been found: Neurogenic, Angiogenic, Impingement and “Iceberg” Hypotheses. Multiple databases were utilized for articles published between 1964 and 2013. The different hypothesis were analyzed, differently considering those concerning the pathogenesis of tendinopathy and those concerning the etiology of complaints in patients. This review of the literature demonstrates the heterogeneity of Achilles tendinopathy pathogenesis. 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| ispartof | Foot and ankle surgery, 2014-09, Vol.20 (3), p.154-159 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Achilles pathogenesis Achilles tendinopathy Achilles Tendon Humans Orthopedics Risk Factors Tendinopathy - etiology Tendinopathy - therapy Tendon degeneration |
| title | The pathogenesis of Achilles tendinopathy: A systematic review |
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