Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia

Human immunodeficiency virus (HIV) infection is commonly associated with neurological disease that occurs in the apparent absence of extensive infection of brain cells by HIV, suggesting that indirect mechanisms account for neuropathogenesis in the CNS, perhaps including changes in the normal neurop...

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Veröffentlicht in:	The Journal of biological chemistry 1996-06, Vol.271 (26), p.15303-15306
Hauptverfasser:	Fine, S M, Angel, R A, Perry, S W, Epstein, L G, Rothstein, J D, Dewhurst, S, Gelbard, H A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Dementia Complex - etiology Astrocytes - metabolism Biological Transport Cells, Cultured Fetus Glutamates - metabolism HIV Infections - physiopathology human immunodeficiency virus 1 Humans Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
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