Effects of amitraz on nerve conduction and neuromuscular transmission in anaesthetised dogs
Ataxia is an occasional side effect of amitraz when used as a wash to treat dogs with demodectic mange. In the present study, successive doses of 0·5, 2, 5 and 10 mg kg–1 amitraz were given intravenously at intervals of nine minutes to thiopentone/methoxyflurane/oxygen anaesthetised dogs. The amplit...
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| Veröffentlicht in: | Research in veterinary science 1990-03, Vol.48 (2), p.162-164 |
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| creator | CULLEN, L.K. REYNOLDSON, J.A. |
| description | Ataxia is an occasional side effect of amitraz when used as a wash to treat dogs with demodectic mange. In the present study, successive doses of 0·5, 2, 5 and 10 mg kg–1 amitraz were given intravenously at intervals of nine minutes to thiopentone/methoxyflurane/oxygen anaesthetised dogs. The amplitude of the evoked muscle action potential to electrical stimulation of the right ulnar nerve and the muscle refractory period were unchanged by increasing doses of amitraz but there was a progressive and significant decrease in nerve conduction velocity. The minimum recorded nerve conduction velocity (50·7 ± 1·5 m s–1) was still within an adequate range. From these results it appears that the ataxia following amitraz is unlikely to be attributable to peripheral mechanisms. The concurrent amitraz-induced rise in mean arterial pressure and bradycardia was consistent with previous findings in which α2-adrenoceptors were shown to be the major mediators. |
| doi_str_mv | 10.1016/S0034-5288(18)30983-4 |
| format | Article |
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In the present study, successive doses of 0·5, 2, 5 and 10 mg kg–1 amitraz were given intravenously at intervals of nine minutes to thiopentone/methoxyflurane/oxygen anaesthetised dogs. The amplitude of the evoked muscle action potential to electrical stimulation of the right ulnar nerve and the muscle refractory period were unchanged by increasing doses of amitraz but there was a progressive and significant decrease in nerve conduction velocity. The minimum recorded nerve conduction velocity (50·7 ± 1·5 m s–1) was still within an adequate range. From these results it appears that the ataxia following amitraz is unlikely to be attributable to peripheral mechanisms. 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In the present study, successive doses of 0·5, 2, 5 and 10 mg kg–1 amitraz were given intravenously at intervals of nine minutes to thiopentone/methoxyflurane/oxygen anaesthetised dogs. The amplitude of the evoked muscle action potential to electrical stimulation of the right ulnar nerve and the muscle refractory period were unchanged by increasing doses of amitraz but there was a progressive and significant decrease in nerve conduction velocity. The minimum recorded nerve conduction velocity (50·7 ± 1·5 m s–1) was still within an adequate range. From these results it appears that the ataxia following amitraz is unlikely to be attributable to peripheral mechanisms. The concurrent amitraz-induced rise in mean arterial pressure and bradycardia was consistent with previous findings in which α2-adrenoceptors were shown to be the major mediators.</description><subject>Action potential</subject><subject>Action Potentials - drug effects</subject><subject>Anesthesia - veterinary</subject><subject>Animals</subject><subject>Ataxia</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Bradycardia</subject><subject>Dogs</subject><subject>Dogs - physiology</subject><subject>Electrical stimuli</subject><subject>Electromyography</subject><subject>Evoked Potentials - drug effects</subject><subject>Heart Rate - drug effects</subject><subject>Insecticides - toxicity</subject><subject>Muscles</subject><subject>Nerve conduction</subject><subject>Neural Conduction - drug effects</subject><subject>Neuromuscular Junction - drug effects</subject><subject>Neuromuscular junctions</subject><subject>Neuromuscular transmission</subject><subject>Receptors (physiology)</subject><subject>Refractory period</subject><subject>Toluidines - toxicity</subject><subject>Velocity</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtL7TAUhYMoenz8BKEgiA6qO4-26Ugu4gsEB-rIQchJdjRy2mjSCtdfb-o5OHDiKLDXl7VXVgjZp3BCgdan9wBclBWT8ojKYw6t5KVYIzNacVayuqbrZPaDbJHtlF4BQFDabJJNxjkXjM_I04VzaIZUBFfozg9RfxahL3qMH1iY0NvRDD4PdG_zcIyhG5MZFzoWGe1T51OaZD8RGtPwgoNPaAsbntMu2XB6kXBvde6Qx8uLh_Pr8vbu6ub8321pBG2HUrBmLtGh1nxOBatqmBttLTfGIIOGOoAaatu2AJJy3bJGSm5d4xohZCUs3yGHS9-3GN7HHELlWAYXC91jGJOiVc1FfnoGD36Br2GMfc6mGFTQiirvy1S1pEwMKUV06i36Tsf_ioKaqlff1aupV0Wl-q5eTe77K_dx3qH9ubXqOutnSx1zFx8eo0rGY2_Q-pi_QNng_9jwBbnvk18</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>CULLEN, L.K.</creator><creator>REYNOLDSON, J.A.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>19900301</creationdate><title>Effects of amitraz on nerve conduction and neuromuscular transmission in anaesthetised dogs</title><author>CULLEN, L.K. ; REYNOLDSON, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-427b8efeaa3b142560bcadd3ccce2071f00606d9900813a927883df7f744854d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Action potential</topic><topic>Action Potentials - drug effects</topic><topic>Anesthesia - veterinary</topic><topic>Animals</topic><topic>Ataxia</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Bradycardia</topic><topic>Dogs</topic><topic>Dogs - physiology</topic><topic>Electrical stimuli</topic><topic>Electromyography</topic><topic>Evoked Potentials - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>Insecticides - toxicity</topic><topic>Muscles</topic><topic>Nerve conduction</topic><topic>Neural Conduction - drug effects</topic><topic>Neuromuscular Junction - drug effects</topic><topic>Neuromuscular junctions</topic><topic>Neuromuscular transmission</topic><topic>Receptors (physiology)</topic><topic>Refractory period</topic><topic>Toluidines - toxicity</topic><topic>Velocity</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CULLEN, L.K.</creatorcontrib><creatorcontrib>REYNOLDSON, J.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CULLEN, L.K.</au><au>REYNOLDSON, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of amitraz on nerve conduction and neuromuscular transmission in anaesthetised dogs</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>48</volume><issue>2</issue><spage>162</spage><epage>164</epage><pages>162-164</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>Ataxia is an occasional side effect of amitraz when used as a wash to treat dogs with demodectic mange. In the present study, successive doses of 0·5, 2, 5 and 10 mg kg–1 amitraz were given intravenously at intervals of nine minutes to thiopentone/methoxyflurane/oxygen anaesthetised dogs. The amplitude of the evoked muscle action potential to electrical stimulation of the right ulnar nerve and the muscle refractory period were unchanged by increasing doses of amitraz but there was a progressive and significant decrease in nerve conduction velocity. The minimum recorded nerve conduction velocity (50·7 ± 1·5 m s–1) was still within an adequate range. From these results it appears that the ataxia following amitraz is unlikely to be attributable to peripheral mechanisms. 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| subjects | Action potential Action Potentials - drug effects Anesthesia - veterinary Animals Ataxia Blood pressure Blood Pressure - drug effects Bradycardia Dogs Dogs - physiology Electrical stimuli Electromyography Evoked Potentials - drug effects Heart Rate - drug effects Insecticides - toxicity Muscles Nerve conduction Neural Conduction - drug effects Neuromuscular Junction - drug effects Neuromuscular junctions Neuromuscular transmission Receptors (physiology) Refractory period Toluidines - toxicity Velocity Veterinary medicine |
| title | Effects of amitraz on nerve conduction and neuromuscular transmission in anaesthetised dogs |
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