Discontinuation of sustained sucrose-feeding aggravates morphine withdrawal

Sprague-Dawley rats were allowed ad lib access to a 20% sucrose solution in addition to their normal diet to investigate the relationship between the prolonged consumption of a high carbohydrate diet and opioid function as evidenced by opioid dependence and withdrawal. Morphine dependence, assayed b...

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Veröffentlicht in:	Brain research bulletin 1990-04, Vol.24 (4), p.565-568
Hauptverfasser:	Schoenbaum, Geoffrey M., Martin, R.J., Roane, D.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Biological and medical sciences Feeding Behavior - drug effects Male Medical sciences Morphine Morphine - adverse effects Naloxone Naloxone - pharmacology Neuropharmacology Nociception Opioid dependence Opioid withdrawal Pain - physiopathology Pharmacology. Drug treatments Rats Rats, Inbred Strains Sensory Thresholds - drug effects Substance Withdrawal Syndrome - physiopathology Sucrose Sucrose - physiology
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