Therapeutic Effect of Alprostadil in Diabetic Nephropathy: Possible Roles of Angiopoietin-2 and IL-18

Background/Aims: To investigate the role of angiopoietin-2 (Ang-2) and IL-18 in the pathogenesis of diabetic nephropathy (DN) and the molecular mechanisms through which alprostadil protects renal function. Methods: DN was induced by streptozotocin and intraperitoneal injection of alprostadil was giv...

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Veröffentlicht in:	Cellular physiology and biochemistry 2014-01, Vol.34 (3), p.916-928
Hauptverfasser:	Luo, Changqing, Li, Ting, Zhang, Chun, Chen, Qing, Li, Zhenqiong, Liu, Jianshe, Wang, Yumei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil Alprostadil - therapeutic use Angiopoietin-2 Angiopoietin-2 - physiology Animals Base Sequence Blood Glucose - metabolism Cells, Cultured Diabetic Nephropathies - drug therapy Diabetic Nephropathies - physiopathology Diabetic Nephropathy DNA Primers Glomerular endothelial cells Glucose - administration & dosage Glycated Hemoglobin A - metabolism IL-18 Interleukin-18 - physiology Male Mice Mice, Inbred C57BL Original Paper Reverse Transcriptase Polymerase Chain Reaction Urological Agents - therapeutic use
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