Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration
Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper under...
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| Veröffentlicht in: | Stem cell reviews 2014-10, Vol.10 (5), p.686-696 |
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| creator | Toh, Wei Seong Foldager, Casper Bindzus Pei, Ming Hui, James Hoi Po |
| description | Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. In this review, we will discuss the emerging role of MSCs in cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration. |
| doi_str_mv | 10.1007/s12015-014-9526-z |
| format | Article |
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Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. 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| subjects | Animals Biomedical and Life Sciences Biomedical Engineering and Bioengineering Cartilage, Articular - cytology Cartilage, Articular - injuries Cell Biology Humans Life Sciences Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - cytology Regeneration Regenerative Medicine/Tissue Engineering Stem Cells Wound Healing |
| title | Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration |
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