Pediatric Plasmablastic Lymphoma: A Clinicopathologic Study
Plasmablastic lymphoma (PBL) is reported rarely in children. To date, 10 cases are documented in the English-language literature. This study, based on 13 biopsies from 11 HIV-positive children (9 males, 2 females), documents the clinicopathologic features of PBL. The CD4 count ranged from 9 to 800 c...
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| Veröffentlicht in: | International journal of surgical pathology 2014-10, Vol.22 (7), p.607-616 |
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| container_title | International journal of surgical pathology |
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| creator | Vaubell, Jalaludin I. Sing, Yetish Ramburan, Amsha Sewram, Vikash Thejpal, Rajendra Rapiti, Nadine Ramdial, Pratistadevi K. |
| description | Plasmablastic lymphoma (PBL) is reported rarely in children. To date, 10 cases are documented in the English-language literature. This study, based on 13 biopsies from 11 HIV-positive children (9 males, 2 females), documents the clinicopathologic features of PBL. The CD4 count ranged from 9 to 800 cells/mm3. All biopsies demonstrated exclusive plasmablastic morphology; CD20 immunonegativity; and VS38c, EMA, CD31, MUM-1, CD45, and CD79a immunopositivity. B-cell monoclonality was confirmed in all biopsies. Of 3 biopsies subjected to FISH investigation, 2 had a t(8,14) translocation. Nine patients with follow-up details were treated exclusively with HAART (highly active antiretroviral therapy) or with combinations of HAART, chemotherapy, and radiotherapy. Seven patients died. PBL histomorphology, disease stage, and treatment modalities employed were not predictive of outcome. The survival of 2 stage 4 patients for 3 and 8 years each, managed on HAART, chemotherapy, and radiotherapy, however, may justify a role for combined therapeutic modalities for PBL. |
| doi_str_mv | 10.1177/1066896914531815 |
| format | Article |
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To date, 10 cases are documented in the English-language literature. This study, based on 13 biopsies from 11 HIV-positive children (9 males, 2 females), documents the clinicopathologic features of PBL. The CD4 count ranged from 9 to 800 cells/mm3. All biopsies demonstrated exclusive plasmablastic morphology; CD20 immunonegativity; and VS38c, EMA, CD31, MUM-1, CD45, and CD79a immunopositivity. B-cell monoclonality was confirmed in all biopsies. Of 3 biopsies subjected to FISH investigation, 2 had a t(8,14) translocation. Nine patients with follow-up details were treated exclusively with HAART (highly active antiretroviral therapy) or with combinations of HAART, chemotherapy, and radiotherapy. Seven patients died. PBL histomorphology, disease stage, and treatment modalities employed were not predictive of outcome. The survival of 2 stage 4 patients for 3 and 8 years each, managed on HAART, chemotherapy, and radiotherapy, however, may justify a role for combined therapeutic modalities for PBL.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/1066896914531815</identifier><identifier>PMID: 24771257</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Antiretroviral Therapy, Highly Active ; Child ; Child, Preschool ; Female ; HIV Infections - complications ; HIV Infections - drug therapy ; Humans ; Lymphoma, Large B-Cell, Diffuse - genetics ; Lymphoma, Large B-Cell, Diffuse - pathology ; Lymphoma, Large B-Cell, Diffuse - virology ; Male</subject><ispartof>International journal of surgical pathology, 2014-10, Vol.22 (7), p.607-616</ispartof><rights>The Author(s) 2014</rights><rights>The Author(s) 2014.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c290t-79a8124dd3e6b7eb46fe1bdd39ef0548f0d388b41e957db818018b03e47cd2773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1066896914531815$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1066896914531815$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24771257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaubell, Jalaludin I.</creatorcontrib><creatorcontrib>Sing, Yetish</creatorcontrib><creatorcontrib>Ramburan, Amsha</creatorcontrib><creatorcontrib>Sewram, Vikash</creatorcontrib><creatorcontrib>Thejpal, Rajendra</creatorcontrib><creatorcontrib>Rapiti, Nadine</creatorcontrib><creatorcontrib>Ramdial, Pratistadevi K.</creatorcontrib><title>Pediatric Plasmablastic Lymphoma: A Clinicopathologic Study</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>Plasmablastic lymphoma (PBL) is reported rarely in children. To date, 10 cases are documented in the English-language literature. This study, based on 13 biopsies from 11 HIV-positive children (9 males, 2 females), documents the clinicopathologic features of PBL. The CD4 count ranged from 9 to 800 cells/mm3. All biopsies demonstrated exclusive plasmablastic morphology; CD20 immunonegativity; and VS38c, EMA, CD31, MUM-1, CD45, and CD79a immunopositivity. B-cell monoclonality was confirmed in all biopsies. Of 3 biopsies subjected to FISH investigation, 2 had a t(8,14) translocation. Nine patients with follow-up details were treated exclusively with HAART (highly active antiretroviral therapy) or with combinations of HAART, chemotherapy, and radiotherapy. Seven patients died. PBL histomorphology, disease stage, and treatment modalities employed were not predictive of outcome. The survival of 2 stage 4 patients for 3 and 8 years each, managed on HAART, chemotherapy, and radiotherapy, however, may justify a role for combined therapeutic modalities for PBL.</description><subject>Adolescent</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>Humans</subject><subject>Lymphoma, Large B-Cell, Diffuse - genetics</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Lymphoma, Large B-Cell, Diffuse - virology</subject><subject>Male</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UDtPwzAQthCIlsLOhDqyBO4cP0dU8ZIq0QFmy44dSJU0xU6G_nuMWhiQWO7u0_eQ7iPkEuEGUcpbBCGUFhoZL1EhPyJT1AwKygQ_znemi29-Qs5SWgMAFRRPyYQyKZFyOSXzVfCNHWJTzVetTZ11eQ4ZLXfd9qPv7Dk5qW2bwsVhz8jbw_3r4qlYvjw-L-6WRUU1DIXUViFl3pdBOBkcE3VAl6EONXCmavClUo5h0Fx6p1ABKgdlYLLyVMpyRq73udvYf44hDaZrUhXa1m5CPyaDXJQgkIHKUthLq9inFENttrHpbNwZBPPdi_nbS7ZcHdJH1wX_a_gpIguKvSDZ92DW_Rg3-dv_A78AQIloWQ</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Vaubell, Jalaludin I.</creator><creator>Sing, Yetish</creator><creator>Ramburan, Amsha</creator><creator>Sewram, Vikash</creator><creator>Thejpal, Rajendra</creator><creator>Rapiti, Nadine</creator><creator>Ramdial, Pratistadevi K.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Pediatric Plasmablastic Lymphoma</title><author>Vaubell, Jalaludin I. ; Sing, Yetish ; Ramburan, Amsha ; Sewram, Vikash ; Thejpal, Rajendra ; Rapiti, Nadine ; Ramdial, Pratistadevi K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-79a8124dd3e6b7eb46fe1bdd39ef0548f0d388b41e957db818018b03e47cd2773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>Humans</topic><topic>Lymphoma, Large B-Cell, Diffuse - genetics</topic><topic>Lymphoma, Large B-Cell, Diffuse - pathology</topic><topic>Lymphoma, Large B-Cell, Diffuse - virology</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaubell, Jalaludin I.</creatorcontrib><creatorcontrib>Sing, Yetish</creatorcontrib><creatorcontrib>Ramburan, Amsha</creatorcontrib><creatorcontrib>Sewram, Vikash</creatorcontrib><creatorcontrib>Thejpal, Rajendra</creatorcontrib><creatorcontrib>Rapiti, Nadine</creatorcontrib><creatorcontrib>Ramdial, Pratistadevi K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaubell, Jalaludin I.</au><au>Sing, Yetish</au><au>Ramburan, Amsha</au><au>Sewram, Vikash</au><au>Thejpal, Rajendra</au><au>Rapiti, Nadine</au><au>Ramdial, Pratistadevi K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric Plasmablastic Lymphoma: A Clinicopathologic Study</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2014-10</date><risdate>2014</risdate><volume>22</volume><issue>7</issue><spage>607</spage><epage>616</epage><pages>607-616</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>Plasmablastic lymphoma (PBL) is reported rarely in children. To date, 10 cases are documented in the English-language literature. This study, based on 13 biopsies from 11 HIV-positive children (9 males, 2 females), documents the clinicopathologic features of PBL. The CD4 count ranged from 9 to 800 cells/mm3. All biopsies demonstrated exclusive plasmablastic morphology; CD20 immunonegativity; and VS38c, EMA, CD31, MUM-1, CD45, and CD79a immunopositivity. B-cell monoclonality was confirmed in all biopsies. Of 3 biopsies subjected to FISH investigation, 2 had a t(8,14) translocation. Nine patients with follow-up details were treated exclusively with HAART (highly active antiretroviral therapy) or with combinations of HAART, chemotherapy, and radiotherapy. Seven patients died. PBL histomorphology, disease stage, and treatment modalities employed were not predictive of outcome. The survival of 2 stage 4 patients for 3 and 8 years each, managed on HAART, chemotherapy, and radiotherapy, however, may justify a role for combined therapeutic modalities for PBL.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>24771257</pmid><doi>10.1177/1066896914531815</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Antiretroviral Therapy, Highly Active Child Child, Preschool Female HIV Infections - complications HIV Infections - drug therapy Humans Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Large B-Cell, Diffuse - virology Male |
| title | Pediatric Plasmablastic Lymphoma: A Clinicopathologic Study |
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