Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study
Cardiovascular magnetization transfer ratio (MTR) imaging by steady state free precession is a promising imaging method to assess microstructural changes within the myocardium. Hence, MTR imaging was correlated to histological analysis. Three postmortem cases were selected based on a suspicion of my...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2014-10, Vol.40 (4), p.915-919 |
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| creator | Crooijmans, Hendrikus J.A. Ruder, Thomas D. Zech, Wolf-Dieter Somaini, Sandra Scheffler, Klaus Thali, Michael J. Bieri, Oliver |
| description | Cardiovascular magnetization transfer ratio (MTR) imaging by steady state free precession is a promising imaging method to assess microstructural changes within the myocardium. Hence, MTR imaging was correlated to histological analysis. Three postmortem cases were selected based on a suspicion of myocardial infarction. MTR and T2‐weighted (T2w) imaging was performed, followed by autopsy and histological analysis. All tissue abnormalities, identified by autopsy or histology, were retrospectively selected on visually matched MTR and T2w images, and corresponding MTR values compared with normal appearing tissue. Regions of elevated MTR (up to approximately 20%, as compared to normal tissue), appearing hypo‐intense in T2w‐images, revealed the presence of fibrous tissue in microscopic histological analysis. Macroscopic observation (autopsy) described scar tissue only in one case. Regions of reduced MTR (up to approximately 20%) corresponded either to (i) the presence of edema, appearing hyperintense in T2w‐images and confirmed by autopsy, or to (ii) inflammatory granulocyte infiltration at a microscopic level, appearing as hypo‐intense T2w‐signal, but not observed by autopsy. Findings from cardiovascular MTR imaging corresponded to histology results. In contrast to T2w‐imaging, MTR imaging discriminated between normal myocardium, scar tissue and regions of acute myocardial infarction in all three cases. J. Magn. Reson. Imaging 2014;40:915–919. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmri.24460 |
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Hence, MTR imaging was correlated to histological analysis. Three postmortem cases were selected based on a suspicion of myocardial infarction. MTR and T2‐weighted (T2w) imaging was performed, followed by autopsy and histological analysis. All tissue abnormalities, identified by autopsy or histology, were retrospectively selected on visually matched MTR and T2w images, and corresponding MTR values compared with normal appearing tissue. Regions of elevated MTR (up to approximately 20%, as compared to normal tissue), appearing hypo‐intense in T2w‐images, revealed the presence of fibrous tissue in microscopic histological analysis. Macroscopic observation (autopsy) described scar tissue only in one case. Regions of reduced MTR (up to approximately 20%) corresponded either to (i) the presence of edema, appearing hyperintense in T2w‐images and confirmed by autopsy, or to (ii) inflammatory granulocyte infiltration at a microscopic level, appearing as hypo‐intense T2w‐signal, but not observed by autopsy. Findings from cardiovascular MTR imaging corresponded to histology results. In contrast to T2w‐imaging, MTR imaging discriminated between normal myocardium, scar tissue and regions of acute myocardial infarction in all three cases. J. Magn. Reson. Imaging 2014;40:915–919. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.24460</identifier><identifier>PMID: 24227690</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Cadaver ; Feasibility Studies ; Female ; histology ; Humans ; Image Interpretation, Computer-Assisted - methods ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; magnetization transfer ratio ; Male ; Middle Aged ; myocardial infarct ; Myocardial Infarction - pathology ; Reproducibility of Results ; Sensitivity and Specificity ; steady state free-precession ; virtopsy</subject><ispartof>Journal of magnetic resonance imaging, 2014-10, Vol.40 (4), p.915-919</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4640-b738a42fd270063e9bf66d066af915a4422834310e6ae196d78aed10c1b0fb1b3</citedby><cites>FETCH-LOGICAL-c4640-b738a42fd270063e9bf66d066af915a4422834310e6ae196d78aed10c1b0fb1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.24460$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.24460$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24227690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crooijmans, Hendrikus J.A.</creatorcontrib><creatorcontrib>Ruder, Thomas D.</creatorcontrib><creatorcontrib>Zech, Wolf-Dieter</creatorcontrib><creatorcontrib>Somaini, Sandra</creatorcontrib><creatorcontrib>Scheffler, Klaus</creatorcontrib><creatorcontrib>Thali, Michael J.</creatorcontrib><creatorcontrib>Bieri, Oliver</creatorcontrib><title>Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Cardiovascular magnetization transfer ratio (MTR) imaging by steady state free precession is a promising imaging method to assess microstructural changes within the myocardium. Hence, MTR imaging was correlated to histological analysis. Three postmortem cases were selected based on a suspicion of myocardial infarction. MTR and T2‐weighted (T2w) imaging was performed, followed by autopsy and histological analysis. All tissue abnormalities, identified by autopsy or histology, were retrospectively selected on visually matched MTR and T2w images, and corresponding MTR values compared with normal appearing tissue. Regions of elevated MTR (up to approximately 20%, as compared to normal tissue), appearing hypo‐intense in T2w‐images, revealed the presence of fibrous tissue in microscopic histological analysis. Macroscopic observation (autopsy) described scar tissue only in one case. Regions of reduced MTR (up to approximately 20%) corresponded either to (i) the presence of edema, appearing hyperintense in T2w‐images and confirmed by autopsy, or to (ii) inflammatory granulocyte infiltration at a microscopic level, appearing as hypo‐intense T2w‐signal, but not observed by autopsy. Findings from cardiovascular MTR imaging corresponded to histology results. In contrast to T2w‐imaging, MTR imaging discriminated between normal myocardium, scar tissue and regions of acute myocardial infarction in all three cases. J. Magn. Reson. Imaging 2014;40:915–919. © 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Cadaver</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>histology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>magnetization transfer ratio</subject><subject>Male</subject><subject>Middle Aged</subject><subject>myocardial infarct</subject><subject>Myocardial Infarction - pathology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>steady state free-precession</subject><subject>virtopsy</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0Eol9c-AHIEheElDL-Tri1S7sUSpFQEdwsJ3G2XpJ4sR3K9tfXy7Y9cOjJY80zr2YehF4SOCQA9N1yCO6Qci7hCdolgtKCilI-zTUIVpAS1A7ai3EJAFXFxXO0QzmlSlawi_TMhNb5PyY2U28CHsxitMndmOT8iFMwY-xswGHzxy533bjAjR9WJtgWX7t0ha9cTL73i_V7fIRXPqbBh2QHHNPUrg_Qs8700b64e_fR99OTy9nH4vzr_Gx2dF40XHIoasVKw2nXUgUgma3qTsoWpDRdRYThed-ScUbASmNJJVtVGtsSaEgNXU1qto_ebHNXwf-ebEx6cLGxfW9G66eoiZAMRKlUldHX_6FLP4Uxb7ehKOGVEjxTb7dUE3yMwXZ6FfL9Ya0J6I12vdGu_2nP8Ku7yKkebPuA3nvOANkC166360ei9Kcv387uQ4vtTPZr_z7MmPBLS8WU0D8u5npe_Tz9cHF5rD-zWw_JnP0</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Crooijmans, Hendrikus J.A.</creator><creator>Ruder, Thomas D.</creator><creator>Zech, Wolf-Dieter</creator><creator>Somaini, Sandra</creator><creator>Scheffler, Klaus</creator><creator>Thali, Michael J.</creator><creator>Bieri, Oliver</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study</title><author>Crooijmans, Hendrikus J.A. ; Ruder, Thomas D. ; Zech, Wolf-Dieter ; Somaini, Sandra ; Scheffler, Klaus ; Thali, Michael J. ; Bieri, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4640-b738a42fd270063e9bf66d066af915a4422834310e6ae196d78aed10c1b0fb1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Cadaver</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>histology</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>magnetization transfer ratio</topic><topic>Male</topic><topic>Middle Aged</topic><topic>myocardial infarct</topic><topic>Myocardial Infarction - pathology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>steady state free-precession</topic><topic>virtopsy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crooijmans, Hendrikus J.A.</creatorcontrib><creatorcontrib>Ruder, Thomas D.</creatorcontrib><creatorcontrib>Zech, Wolf-Dieter</creatorcontrib><creatorcontrib>Somaini, Sandra</creatorcontrib><creatorcontrib>Scheffler, Klaus</creatorcontrib><creatorcontrib>Thali, Michael J.</creatorcontrib><creatorcontrib>Bieri, Oliver</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crooijmans, Hendrikus J.A.</au><au>Ruder, Thomas D.</au><au>Zech, Wolf-Dieter</au><au>Somaini, Sandra</au><au>Scheffler, Klaus</au><au>Thali, Michael J.</au><au>Bieri, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2014-10</date><risdate>2014</risdate><volume>40</volume><issue>4</issue><spage>915</spage><epage>919</epage><pages>915-919</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Cardiovascular magnetization transfer ratio (MTR) imaging by steady state free precession is a promising imaging method to assess microstructural changes within the myocardium. Hence, MTR imaging was correlated to histological analysis. Three postmortem cases were selected based on a suspicion of myocardial infarction. MTR and T2‐weighted (T2w) imaging was performed, followed by autopsy and histological analysis. All tissue abnormalities, identified by autopsy or histology, were retrospectively selected on visually matched MTR and T2w images, and corresponding MTR values compared with normal appearing tissue. Regions of elevated MTR (up to approximately 20%, as compared to normal tissue), appearing hypo‐intense in T2w‐images, revealed the presence of fibrous tissue in microscopic histological analysis. Macroscopic observation (autopsy) described scar tissue only in one case. Regions of reduced MTR (up to approximately 20%) corresponded either to (i) the presence of edema, appearing hyperintense in T2w‐images and confirmed by autopsy, or to (ii) inflammatory granulocyte infiltration at a microscopic level, appearing as hypo‐intense T2w‐signal, but not observed by autopsy. Findings from cardiovascular MTR imaging corresponded to histology results. In contrast to T2w‐imaging, MTR imaging discriminated between normal myocardium, scar tissue and regions of acute myocardial infarction in all three cases. J. Magn. Reson. Imaging 2014;40:915–919. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24227690</pmid><doi>10.1002/jmri.24460</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Cadaver Feasibility Studies Female histology Humans Image Interpretation, Computer-Assisted - methods Magnetic resonance imaging Magnetic Resonance Imaging - methods magnetization transfer ratio Male Middle Aged myocardial infarct Myocardial Infarction - pathology Reproducibility of Results Sensitivity and Specificity steady state free-precession virtopsy |
| title | Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study |
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