Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention
Since the first description of the association between chronic kidney disease and heart disease, many epidemiological studies have confirmed and extended this finding. As chronic kidney disease progresses, kidney-specific risk factors for cardiovascular events and disease come into play. As a result...
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| Veröffentlicht in: | The Lancet (British edition) 2013-07, Vol.382 (9889), p.339-352 |
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| creator | Gansevoort, Ron T, Dr Correa-Rotter, Ricardo, Prof Hemmelgarn, Brenda R, Prof Jafar, Tazeen H, Prof Heerspink, Hiddo J Lambers, PharmSc Mann, Johannes F, Prof Matsushita, Kunihiro, MD Wen, Chi Pang, Prof |
| description | Since the first description of the association between chronic kidney disease and heart disease, many epidemiological studies have confirmed and extended this finding. As chronic kidney disease progresses, kidney-specific risk factors for cardiovascular events and disease come into play. As a result, the risk for cardiovascular disease is notably increased in individuals with chronic kidney disease. When adjusted for traditional cardiovascular risk factors, impaired kidney function and raised concentrations of albumin in urine increase the risk of cardiovascular disease by two to four times. Yet, cardiovascular disease is frequently underdiagnosed and undertreated in patients with chronic kidney disease. This group of patients should, therefore, be acknowledged as having high cardiovascular risk that needs particular medical attention at an individual level. This view should be incorporated in the development of guidelines and when defining research priorities. Here, we discuss the epidemiology and pathophysiological mechanisms of cardiovascular risk in patients with chronic kidney disease, and discuss methods of prevention. |
| doi_str_mv | 10.1016/S0140-6736(13)60595-4 |
| format | Article |
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As chronic kidney disease progresses, kidney-specific risk factors for cardiovascular events and disease come into play. As a result, the risk for cardiovascular disease is notably increased in individuals with chronic kidney disease. When adjusted for traditional cardiovascular risk factors, impaired kidney function and raised concentrations of albumin in urine increase the risk of cardiovascular disease by two to four times. Yet, cardiovascular disease is frequently underdiagnosed and undertreated in patients with chronic kidney disease. This group of patients should, therefore, be acknowledged as having high cardiovascular risk that needs particular medical attention at an individual level. This view should be incorporated in the development of guidelines and when defining research priorities. Here, we discuss the epidemiology and pathophysiological mechanisms of cardiovascular risk in patients with chronic kidney disease, and discuss methods of prevention.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(13)60595-4</identifier><identifier>PMID: 23727170</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>albumins ; Albuminuria - complications ; Biological and medical sciences ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - prevention & control ; Cost of Illness ; Diabetes ; epidemiological studies ; Epidemiology ; Female ; General aspects ; Glomerular Filtration Rate ; guidelines ; Health risks ; heart diseases ; Humans ; Hypertension ; Internal Medicine ; kidney diseases ; Kidneys ; Life Expectancy ; Male ; Medical sciences ; Mortality ; Nephrology. 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All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 27, 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c719t-d971ffb33bbf7c67a4c7c13e9d8b852af0f6ddafff22640e46bc6e12f121a2043</citedby><cites>FETCH-LOGICAL-c719t-d971ffb33bbf7c67a4c7c13e9d8b852af0f6ddafff22640e46bc6e12f121a2043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1412581061?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27537217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23727170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gansevoort, Ron T, Dr</creatorcontrib><creatorcontrib>Correa-Rotter, Ricardo, Prof</creatorcontrib><creatorcontrib>Hemmelgarn, Brenda R, Prof</creatorcontrib><creatorcontrib>Jafar, Tazeen H, Prof</creatorcontrib><creatorcontrib>Heerspink, Hiddo J Lambers, PharmSc</creatorcontrib><creatorcontrib>Mann, Johannes F, Prof</creatorcontrib><creatorcontrib>Matsushita, Kunihiro, MD</creatorcontrib><creatorcontrib>Wen, Chi Pang, Prof</creatorcontrib><title>Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Since the first description of the association between chronic kidney disease and heart disease, many epidemiological studies have confirmed and extended this finding. As chronic kidney disease progresses, kidney-specific risk factors for cardiovascular events and disease come into play. As a result, the risk for cardiovascular disease is notably increased in individuals with chronic kidney disease. When adjusted for traditional cardiovascular risk factors, impaired kidney function and raised concentrations of albumin in urine increase the risk of cardiovascular disease by two to four times. Yet, cardiovascular disease is frequently underdiagnosed and undertreated in patients with chronic kidney disease. This group of patients should, therefore, be acknowledged as having high cardiovascular risk that needs particular medical attention at an individual level. This view should be incorporated in the development of guidelines and when defining research priorities. Here, we discuss the epidemiology and pathophysiological mechanisms of cardiovascular risk in patients with chronic kidney disease, and discuss methods of prevention.</description><subject>albumins</subject><subject>Albuminuria - complications</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Cost of Illness</subject><subject>Diabetes</subject><subject>epidemiological studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Glomerular Filtration Rate</subject><subject>guidelines</subject><subject>Health risks</subject><subject>heart diseases</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Internal Medicine</subject><subject>kidney diseases</subject><subject>Kidneys</subject><subject>Life Expectancy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>patients</subject><subject>Prevention</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>renal function</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>risk</subject><subject>Risk Factors</subject><subject>Urinary system involvement in other diseases. 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Urinary tract diseases</topic><topic>patients</topic><topic>Prevention</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>renal function</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>risk</topic><topic>Risk Factors</topic><topic>Urinary system involvement in other diseases. 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| subjects | albumins Albuminuria - complications Biological and medical sciences Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Cost of Illness Diabetes epidemiological studies Epidemiology Female General aspects Glomerular Filtration Rate guidelines Health risks heart diseases Humans Hypertension Internal Medicine kidney diseases Kidneys Life Expectancy Male Medical sciences Mortality Nephrology. Urinary tract diseases patients Prevention Public health. Hygiene Public health. Hygiene-occupational medicine renal function Renal Insufficiency, Chronic - complications risk Risk Factors Urinary system involvement in other diseases. Miscellaneous urine |
| title | Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention |
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