Renal Uptake of Substrates for Organic Anion Transporters Oat1 and Oat3 and Organic Cation Transporters Oct1 and Oct2 is Altered in Rats with Adenine-Induced Chronic Renal Failure

Chronic renal failure (CRF) leads to decreased drug renal clearance and glomerular filtration rate. However, little is known about renal tubular excretion and reabsorption in CRF. We examined transport activity of renal transporters using rats with adenine-induced CRF. We examined the effect of aden...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2013-03, Vol.102 (3), p.1086-1094
Hauptverfasser:	Komazawa, Hiroki, Yamaguchi, Hiroaki, Hidaka, Kazuhiro, Ogura, Jiro, Kobayashi, Masaki, Iseki, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine adenine-induced CRF Animals Anti-Bacterial Agents - metabolism Body Weight distribution elimination Gene Expression Hypoglycemic Agents - metabolism Kidney - metabolism Kidney - pathology Kidney Failure, Chronic - chemically induced Kidney Failure, Chronic - genetics Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - pathology kidney uptak clearance kidney uptake clearance Male Metformin - metabolism Organic Anion Transport Protein 1 - genetics Organic Anion Transport Protein 1 - metabolism Organic Anion Transporters, Sodium-Independent - genetics Organic Anion Transporters, Sodium-Independent - metabolism Organic Cation Transport Proteins - genetics Organic Cation Transport Proteins - metabolism Organic Cation Transporter 1 - genetics Organic Cation Transporter 1 - metabolism Organic Cation Transporter 2 Penicillin G - metabolism pharmacokinetics Rats Rats, Wistar RNA, Messenger - genetics Serum - metabolism transport transporters
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