Inactivation of DNA by β-propiolactone

β-propiolactone (BPL) is an alkylating agent which reacts with many nucleophilic reagents including nucleic acids and proteins. BPL modifies the structure of nucleic acids after reaction mainly with purine residues (notably guanine). It induces nicks in DNA, cross-linking between DNA and proteins as...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biologicals 1995-09, Vol.23 (3), p.207-211
Hauptverfasser:	Perrin, Pierre, Morgeaux, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacology Alteration Animals Biological activity BPL Cell Line DNA DNA - drug effects DNA, Viral - drug effects Nucleic Acid Conformation - drug effects Propiolactone - pharmacology Rabies virus - genetics Structure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!