Dysregulated phosphorylation and nuclear translocation of cyclic AMP response element binding protein (CREB) in rat liver after chronic ethanol binge

Binge ethanol during chronic ethanol abuse augments liver injury but the underlying mechanism remains unknown. CREB (cyclic AMP response element binding protein) is implicated as a key transcription factor in liver regeneration and hepatic glucose and lipid metabolism. We examined the effects of eth...

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Veröffentlicht in:	European journal of pharmacology 2012-03, Vol.679 (1-3), p.101-108
Hauptverfasser:	Aroor, Annayya R., Jackson, Daniel E., Shukla, Shivendra D.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II Angiotensin II - pharmacology Animals binding proteins Binge body weight carnitine Carnitine O-Palmitoyltransferase - biosynthesis Chronic ethanol CREB CREB-Binding Protein - metabolism cyclic AMP ethanol Ethanol - poisoning fatty liver Fatty Liver, Alcoholic - metabolism glucose hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism in vivo studies lipid metabolism liquid diet liver Liver - drug effects Liver - metabolism liver regeneration Male MAPK messenger RNA mitogen-activated protein kinase Mitogen-Activated Protein Kinases - metabolism MSK-1 nuclear proteins Nuclear translocation pharmacology phosphorylation Phosphorylation - drug effects Protein Transport - drug effects Rats Rats, Sprague-Dawley Signal Transduction - drug effects Steatosis transcription factors
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