Tramadol-induced seizurogenic effect: a possible role of opioid-dependent histamine (H1) receptor activation-linked mechanism

The present study has been designed to investigate the role of opioid receptors, mast cells, and histamine receptors (H 1 subtype) in the seizurogenic effect of tramadol on pentylenetetrazole-treated mice. A single injection of pentylenetetrazole (80 mg kg −1 ) was used to elicit seizure activity in...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2010-01, Vol.381 (1), p.11-19
Hauptverfasser:	Rehni, Ashish K., Singh, Thakur Gurjeet, Singh, Nirmal, Arora, Sandeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Neurosciences Original Article Pharmacology/Toxicology
Online-Zugang:	Volltext
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