Simultaneous determination of oxiracetam and its degraded substance in rat plasma by HPLC-MS/MS and its application to pharmacokinetic study after a single high-dose intravenous administration

A simple, rapid and sensitive reversed-phase ultra-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the simultaneous quantitative determination of oxiracetam and its degraded substance 4-hydroxy-2-oxo-1-pyrrolidine acetic acid (HOPAA) in...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2014-10, Vol.969, p.95-100
Hauptverfasser:	Wan, Xinhuan, Wang, He, Ma, Panqin, Xi, Long, Sun, Jin, He, Zhonggui, Zhang, Xiangrong, Liu, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxy-2-oxo-1-pyrrolidine acetic acid Administration, Intravenous Animals Chromatography, High Pressure Liquid - methods Drug Stability HPLC-MS/MS Least-Squares Analysis Male Oxiracetam Pharmacokinetics Pyrrolidines - administration & dosage Pyrrolidines - blood Pyrrolidines - chemistry Pyrrolidines - pharmacokinetics Rat plasma Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Simultaneous determination Tandem Mass Spectrometry - methods
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