Post-exposure therapy of filovirus infections

Post-exposure therapy of filovirus infections

Highlights • Interventions given 1 hour after Ebola virus exposure were ineffective in nonhuman primates (NHPs), with the exception of monoclonal antibody (mAb)-based therapy and BCX4430. • Adjuvanted mAb therapy offers 100% protection for up to 72 hours after Ebola virus infection. • mAb therapy is...

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Veröffentlicht in:Trends in microbiology (Regular ed.) 2014-08, Vol.22 (8), p.456-463
Hauptverfasser: Wong, Gary, Qiu, Xiangguo, Olinger, Gene G, Kobinger, Gary P
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies, Monoclonal - therapeutic use
Antibodies, Viral - therapeutic use
Antiviral Agents - therapeutic use
Biological Products - therapeutic use
Disease Models, Animal
Ebola
Filoviridae Infections - therapy
filovirus
immunotherapy
Internal Medicine
Marburg
monoclonal antibodies
post-exposure
Post-Exposure Prophylaxis - methods
Primates
Time Factors
Treatment Outcome
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Beschreibung
Zusammenfassung:Highlights • Interventions given 1 hour after Ebola virus exposure were ineffective in nonhuman primates (NHPs), with the exception of monoclonal antibody (mAb)-based therapy and BCX4430. • Adjuvanted mAb therapy offers 100% protection for up to 72 hours after Ebola virus infection. • mAb therapy is effective even after positive confirmation by reverse transcription-quantitative PCR (RT-qPCR) and fever.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2014.04.002