Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne

Protoberberine alkaloids (coralyne and its derivatives), which exhibit antileukemic activity in animal models, have been shown to be potent inducers of topoisomerase (topo) I-DNA cleavable complexes using purified recombinant human DNA topo I. Different from the structurally similar benzophenanthrid...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1996-06, Vol.56 (12), p.2795-2800
Hauptverfasser:	Gatto, B, Sanders, M M, Yu, C, Wu, H Y, Makhey, D, LaVoie, E J, Liu, L F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Base Sequence Benzophenanthridines Berberine Alkaloids - pharmacology Camptothecin - pharmacology Cattle DNA Damage DNA Topoisomerases, Type I - drug effects DNA Topoisomerases, Type II - drug effects Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Escherichia coli Humans Molecular Sequence Data Phenanthridines - pharmacology Topoisomerase I Inhibitors Topoisomerase II Inhibitors Yeasts - drug effects Yeasts - enzymology
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