Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation

Intrathecal oligoclonal bands of the cerebrospinal fluid are considered the most important immunological biomarkers of multiple sclerosis. They typically consist of clonally expanded IgG antibodies that underwent affinity maturation during sustained stimulation by largely unknown antigens. In additi...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2014-10, Vol.137 (Pt 10), p.2703-2714
Hauptverfasser:	BELTRAN, Eduardo, OBERMEIER, Birgit, HOHLFELD, Reinhard, CASANOVA, Bonaventura, DORNMAIR, Klaus, MOSER, Markus, CORET, Francisco, SIMO-CASTELLO, María, BOSCA, Isabel, PEREZ-MIRALLES, Francisco, VILLAR, Luisa M, SENEL, Makbule, TUMANI, Hayrettin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amino Acid Sequence Antibodies, Monoclonal, Humanized - therapeutic use B-Lymphocytes - immunology Bacterial diseases Base Sequence Biological and medical sciences Borrelia infections Cell Proliferation Female Human bacterial diseases Humans Immunoglobulin G - cerebrospinal fluid Immunoglobulin G - genetics Immunoglobulin M - cerebrospinal fluid Immunoglobulin M - genetics Immunomodulators Infectious diseases Inflammation - genetics Inflammation - immunology Male Medical sciences Middle Aged Molecular Sequence Data Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Natalizumab Neurology Pharmacology. Drug treatments Single-Cell Analysis Somatic Hypermutation, Immunoglobulin - genetics Spinal Cord - immunology Spinal Cord - metabolism Tropical bacterial diseases Young Adult
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