Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons
The neurotransmitter phenotype of sympathetic neurons is specified by interactions with the surrounding embryonic tissues. Adrenergic differentiation is elicited early during development in the vicinity of notochord and dorsal aorta and the importance of axial midline tissues for adrenergic differen...
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| Veröffentlicht in: | Development (Cambridge) 1996-07, Vol.122 (7), p.2079-2088 |
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| container_issue | 7 |
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| container_title | Development (Cambridge) |
| container_volume | 122 |
| creator | Reissmann, E Ernsberger, U Francis-West, P H Rueger, D Brickell, P M Rohrer, H |
| description | The neurotransmitter phenotype of sympathetic neurons is specified by interactions with the surrounding embryonic tissues. Adrenergic differentiation is elicited early during development in the vicinity of notochord and dorsal aorta and the importance of axial midline tissues for adrenergic differentiation has been well documented. We now provide evidence that bone morphogenetic proteins, BMP-4 and BMP-7 are signals produced by the dorsal aorta that direct sympathetic neuron differentiation. BMP-4 and BMP-7 are expressed in the dorsal aorta at critical times during sympathetic neuron differentiation and have the ability to enhance the formation of adrenergic sympathetic neurons both in cultures of neural crest cells and when ectopically expressed in the developing embryo. |
| doi_str_mv | 10.1242/dev.122.7.2079 |
| format | Article |
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Adrenergic differentiation is elicited early during development in the vicinity of notochord and dorsal aorta and the importance of axial midline tissues for adrenergic differentiation has been well documented. We now provide evidence that bone morphogenetic proteins, BMP-4 and BMP-7 are signals produced by the dorsal aorta that direct sympathetic neuron differentiation. 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BMP-4 and BMP-7 are expressed in the dorsal aorta at critical times during sympathetic neuron differentiation and have the ability to enhance the formation of adrenergic sympathetic neurons both in cultures of neural crest cells and when ectopically expressed in the developing embryo.</description><subject>Adrenergic Fibers - physiology</subject><subject>Animals</subject><subject>Aorta - chemistry</subject><subject>Aorta - metabolism</subject><subject>Bone Morphogenetic Protein 7</subject><subject>Bone Morphogenetic Proteins</subject><subject>Cell Culture Techniques</subject><subject>Cell Differentiation - physiology</subject><subject>Chick Embryo</subject><subject>Dose-Response Relationship, Drug</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Neural Crest - chemistry</subject><subject>Neural Crest - embryology</subject><subject>Phenotype</subject><subject>Proteins - analysis</subject><subject>Proteins - physiology</subject><subject>Quail</subject><subject>Sympathetic Nervous System - chemistry</subject><subject>Sympathetic Nervous System - embryology</subject><subject>Transforming Growth Factor beta</subject><subject>Transforming Growth Factors - pharmacology</subject><subject>Transforming Growth Factors - physiology</subject><subject>Tyrosine 3-Monooxygenase - analysis</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr3DAUhUVoSSZpttkFtOrOU0l-yFqG0Dwg0E26FpJ1bSvYkiNppszPyT-tzAylqwiBLvee88HRReiGki1lFfthYJ8LtuVbRrg4QxtacV4IysQXtCGiJgUVgl6gyxjfCCFlw_k5Om-blvJWbNDHs9v7aQ8zuIR9j7V3gGcfltEP4CDZDi_BJ7CuqLBy5jMBx9bhNAI2tu8hZKJVyXq3cte2MrkHYVgtIzifDguslhwBJr9YN-B4mBeVtSvWwS54F7-hr72aIlyf3iv0--Hn6_1T8fLr8fn-7qXoKlanQrUCTFmXXQ_5KtVzRhUvq0orDUJTBkaVjTFt3ehal52oe6g07RgVdcmILq_Q9yM3x3nfQUxytrGDaVIO_C5KWjdsPVm4PQq74GMM0Msl2FmFg6RErjuROVAumORy3Uk23J7IOz2D-Sc_LSHPi-N8tMP4xwaQ2vrJDzamKE-f8z_vL92mnb4</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Reissmann, E</creator><creator>Ernsberger, U</creator><creator>Francis-West, P H</creator><creator>Rueger, D</creator><creator>Brickell, P M</creator><creator>Rohrer, H</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19960701</creationdate><title>Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons</title><author>Reissmann, E ; Ernsberger, U ; Francis-West, P H ; Rueger, D ; Brickell, P M ; Rohrer, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-a89ed353cfecfeaaf721a7344babe9b12eda36dd856b5b3c95fe4b1c2195320b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenergic Fibers - physiology</topic><topic>Animals</topic><topic>Aorta - chemistry</topic><topic>Aorta - metabolism</topic><topic>Bone Morphogenetic Protein 7</topic><topic>Bone Morphogenetic Proteins</topic><topic>Cell Culture Techniques</topic><topic>Cell Differentiation - physiology</topic><topic>Chick Embryo</topic><topic>Dose-Response Relationship, Drug</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Neural Crest - chemistry</topic><topic>Neural Crest - embryology</topic><topic>Phenotype</topic><topic>Proteins - analysis</topic><topic>Proteins - physiology</topic><topic>Quail</topic><topic>Sympathetic Nervous System - chemistry</topic><topic>Sympathetic Nervous System - embryology</topic><topic>Transforming Growth Factor beta</topic><topic>Transforming Growth Factors - pharmacology</topic><topic>Transforming Growth Factors - physiology</topic><topic>Tyrosine 3-Monooxygenase - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reissmann, E</creatorcontrib><creatorcontrib>Ernsberger, U</creatorcontrib><creatorcontrib>Francis-West, P H</creatorcontrib><creatorcontrib>Rueger, D</creatorcontrib><creatorcontrib>Brickell, P M</creatorcontrib><creatorcontrib>Rohrer, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reissmann, E</au><au>Ernsberger, U</au><au>Francis-West, P H</au><au>Rueger, D</au><au>Brickell, P M</au><au>Rohrer, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>122</volume><issue>7</issue><spage>2079</spage><epage>2088</epage><pages>2079-2088</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The neurotransmitter phenotype of sympathetic neurons is specified by interactions with the surrounding embryonic tissues. Adrenergic differentiation is elicited early during development in the vicinity of notochord and dorsal aorta and the importance of axial midline tissues for adrenergic differentiation has been well documented. We now provide evidence that bone morphogenetic proteins, BMP-4 and BMP-7 are signals produced by the dorsal aorta that direct sympathetic neuron differentiation. BMP-4 and BMP-7 are expressed in the dorsal aorta at critical times during sympathetic neuron differentiation and have the ability to enhance the formation of adrenergic sympathetic neurons both in cultures of neural crest cells and when ectopically expressed in the developing embryo.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>8681789</pmid><doi>10.1242/dev.122.7.2079</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1996-07, Vol.122 (7), p.2079-2088 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15622222 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Adrenergic Fibers - physiology Animals Aorta - chemistry Aorta - metabolism Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins Cell Culture Techniques Cell Differentiation - physiology Chick Embryo Dose-Response Relationship, Drug Immunohistochemistry In Situ Hybridization Neural Crest - chemistry Neural Crest - embryology Phenotype Proteins - analysis Proteins - physiology Quail Sympathetic Nervous System - chemistry Sympathetic Nervous System - embryology Transforming Growth Factor beta Transforming Growth Factors - pharmacology Transforming Growth Factors - physiology Tyrosine 3-Monooxygenase - analysis |
| title | Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons |
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