Monoclonal Antibodies to Individual Tyrosine-Phosphorylated Protein Substrates of Oncogene-Encoded Tyrosine Kinases

Cellular transformation by oncogenic retro-viruses encoding protein tyrosine kinases coincides with the tyrosine-specific phosphorylation of multiple protein substrates. Previous studies have shown that tyrosine phosphorylation of a protein of 120 kDa, p120, correlated with src transformation in chi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-05, Vol.87 (9), p.3328-3332
Hauptverfasser:	Kanner, Steven B., Reynolds, Albert B., Vines, Richard R., Parsons, J. Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AMINO ACIDS Analytical, structural and metabolic biochemistry ANIMAL CELLS ANIMALS ANTIBODIES Antibodies, Monoclonal Antigen-Antibody Complex Antigens BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOASSAY Biological and medical sciences BIRDS CARBOXYLIC ACIDS Cell Line Cell lines Cell Transformation, Neoplastic CELL TRANSFORMATIONS Cells, Cultured CHEMICAL REACTIONS Chick Embryo CHICKENS DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES EMBRYONIC CELLS ENZYME IMMUNOASSAY Enzyme-Linked Immunosorbent Assay ENZYMES Enzymes and enzyme inhibitors FOWL Fundamental and applied biological sciences. Psychology GENES Humans HYDROXY ACIDS IMMUNOASSAY Immunoblotting Immunoglobulin G Immunoglobulin M Immunoprecipitation INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IODINE 125 IODINE ISOTOPES ISOTOPES MICROORGANISMS MONOCLONAL ANTIBODIES NUCLEI ODD-EVEN NUCLEI Oncogene Protein pp60(v-src) - genetics Oncogene Protein pp60(v-src) - metabolism ONCOGENES ONCOGENIC TRANSFORMATIONS ORGANIC ACIDS ORGANIC COMPOUNDS PARASITES Phosphoproteins Phosphoproteins - analysis PHOSPHORUS-GROUP TRANSFERASES PHOSPHORYLATION PHOSPHOTRANSFERASES Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteins RADIOASSAY RADIOISOTOPES Spleen cells SUBSTRATES TRANSFERASES TYROSINE VERTEBRATES VIRUSES
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