Use of Crowdsourcing for Cancer Clinical Trial Development
Patient and physician awareness and acceptance of trials and patient ineligibility are major cancer clinical trial accrual barriers. Yet, trials are typically conceived and designed by small teams of researchers with limited patient input. We hypothesized that through crowdsourcing, the intellectual...
Gespeichert in:
| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 2014-10, Vol.106 (10), p.1 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 1 |
| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 106 |
| creator | LEITER, Amanda SABLINSKI, Tomasz DIEFENBACH, Michael FOSTER, Marc GREENBERG, Alex HOLLAND, John OH, William K GALSKY, Matthew D |
| description | Patient and physician awareness and acceptance of trials and patient ineligibility are major cancer clinical trial accrual barriers. Yet, trials are typically conceived and designed by small teams of researchers with limited patient input. We hypothesized that through crowdsourcing, the intellectual and creative capacity of a large number of researchers, clinicians, and patients could be harnessed to improve the clinical trial design process. In this study, we evaluated the feasibility and utility of using an internet-based crowdsourcing platform to inform the design of a clinical trial exploring an antidiabetic drug, metformin, in prostate cancer. Over a six-week period, crowd-sourced input was collected from 60 physicians/researchers and 42 patients/advocates leading to several major (eg, eligibility) and minor modifications to the clinical trial protocol as originally designed. Crowdsourcing clinical trial design is feasible, adds value to the protocol development process, and may ultimately improve the efficiency of trial conduct. |
| doi_str_mv | 10.1093/jnci/dju258 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1561979989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3482791431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-5fb97990e20401cb886a475522cb01994df373b78aa85e470b528e3b7ffa14253</originalsourceid><addsrcrecordid>eNpdkEtLxDAQgIMo7vo4eZeCCILUTdKkSbxJfcKCl91zSNNEUtpmTbaK_94suyo4hxkYPubxAXCG4A2Copi1g3azph0x5XtgikgJc4wg3QdTCDHLOWdkAo5ibGEKgckhmGCKEaMcTsHtMprM26wK_rOJfgzaDW-Z9SGr1KBNKp0bnFZdtggu5XvzYTq_6s2wPgEHVnXRnO7qMVg-Piyq53z--vRS3c1zXRC2zqmtBRMCGgwJRLrmvFSEUYqxriESgjS2YEXNuFKcGsJgTTE3qWGtQgTT4hhcbeeugn8fTVzL3kVtuk4Nxo9RIlqizQYuEnrxD23TS0O6TqIy7ceQoyJR11tKBx9jMFaugutV-JIIyo1SuVEqt0oTfb6bOda9aX7ZH4cJuNwBKiZRNiRxLv5xAqbLSlx8A7HmfSA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1620420813</pqid></control><display><type>article</type><title>Use of Crowdsourcing for Cancer Clinical Trial Development</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>LEITER, Amanda ; SABLINSKI, Tomasz ; DIEFENBACH, Michael ; FOSTER, Marc ; GREENBERG, Alex ; HOLLAND, John ; OH, William K ; GALSKY, Matthew D</creator><creatorcontrib>LEITER, Amanda ; SABLINSKI, Tomasz ; DIEFENBACH, Michael ; FOSTER, Marc ; GREENBERG, Alex ; HOLLAND, John ; OH, William K ; GALSKY, Matthew D</creatorcontrib><description>Patient and physician awareness and acceptance of trials and patient ineligibility are major cancer clinical trial accrual barriers. Yet, trials are typically conceived and designed by small teams of researchers with limited patient input. We hypothesized that through crowdsourcing, the intellectual and creative capacity of a large number of researchers, clinicians, and patients could be harnessed to improve the clinical trial design process. In this study, we evaluated the feasibility and utility of using an internet-based crowdsourcing platform to inform the design of a clinical trial exploring an antidiabetic drug, metformin, in prostate cancer. Over a six-week period, crowd-sourced input was collected from 60 physicians/researchers and 42 patients/advocates leading to several major (eg, eligibility) and minor modifications to the clinical trial protocol as originally designed. Crowdsourcing clinical trial design is feasible, adds value to the protocol development process, and may ultimately improve the efficiency of trial conduct.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/dju258</identifier><identifier>PMID: 25217580</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Clinical trials ; Clinical Trials as Topic - methods ; Crowdsourcing ; Crowdsourcing - methods ; Feasibility ; Feasibility Studies ; Humans ; Internet ; Male ; Medical sciences ; Metformin - therapeutic use ; Neoplasms - therapy ; Patient Selection ; Prostatic Neoplasms - drug therapy ; Protocol ; Research Design ; Tumors</subject><ispartof>JNCI : Journal of the National Cancer Institute, 2014-10, Vol.106 (10), p.1</ispartof><rights>2015 INIST-CNRS</rights><rights>The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford Publishing Limited(England) Oct 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-5fb97990e20401cb886a475522cb01994df373b78aa85e470b528e3b7ffa14253</citedby><cites>FETCH-LOGICAL-c347t-5fb97990e20401cb886a475522cb01994df373b78aa85e470b528e3b7ffa14253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29089362$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25217580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEITER, Amanda</creatorcontrib><creatorcontrib>SABLINSKI, Tomasz</creatorcontrib><creatorcontrib>DIEFENBACH, Michael</creatorcontrib><creatorcontrib>FOSTER, Marc</creatorcontrib><creatorcontrib>GREENBERG, Alex</creatorcontrib><creatorcontrib>HOLLAND, John</creatorcontrib><creatorcontrib>OH, William K</creatorcontrib><creatorcontrib>GALSKY, Matthew D</creatorcontrib><title>Use of Crowdsourcing for Cancer Clinical Trial Development</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>Patient and physician awareness and acceptance of trials and patient ineligibility are major cancer clinical trial accrual barriers. Yet, trials are typically conceived and designed by small teams of researchers with limited patient input. We hypothesized that through crowdsourcing, the intellectual and creative capacity of a large number of researchers, clinicians, and patients could be harnessed to improve the clinical trial design process. In this study, we evaluated the feasibility and utility of using an internet-based crowdsourcing platform to inform the design of a clinical trial exploring an antidiabetic drug, metformin, in prostate cancer. Over a six-week period, crowd-sourced input was collected from 60 physicians/researchers and 42 patients/advocates leading to several major (eg, eligibility) and minor modifications to the clinical trial protocol as originally designed. Crowdsourcing clinical trial design is feasible, adds value to the protocol development process, and may ultimately improve the efficiency of trial conduct.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clinical trials</subject><subject>Clinical Trials as Topic - methods</subject><subject>Crowdsourcing</subject><subject>Crowdsourcing - methods</subject><subject>Feasibility</subject><subject>Feasibility Studies</subject><subject>Humans</subject><subject>Internet</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metformin - therapeutic use</subject><subject>Neoplasms - therapy</subject><subject>Patient Selection</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Protocol</subject><subject>Research Design</subject><subject>Tumors</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLxDAQgIMo7vo4eZeCCILUTdKkSbxJfcKCl91zSNNEUtpmTbaK_94suyo4hxkYPubxAXCG4A2Copi1g3azph0x5XtgikgJc4wg3QdTCDHLOWdkAo5ibGEKgckhmGCKEaMcTsHtMprM26wK_rOJfgzaDW-Z9SGr1KBNKp0bnFZdtggu5XvzYTq_6s2wPgEHVnXRnO7qMVg-Piyq53z--vRS3c1zXRC2zqmtBRMCGgwJRLrmvFSEUYqxriESgjS2YEXNuFKcGsJgTTE3qWGtQgTT4hhcbeeugn8fTVzL3kVtuk4Nxo9RIlqizQYuEnrxD23TS0O6TqIy7ceQoyJR11tKBx9jMFaugutV-JIIyo1SuVEqt0oTfb6bOda9aX7ZH4cJuNwBKiZRNiRxLv5xAqbLSlx8A7HmfSA</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>LEITER, Amanda</creator><creator>SABLINSKI, Tomasz</creator><creator>DIEFENBACH, Michael</creator><creator>FOSTER, Marc</creator><creator>GREENBERG, Alex</creator><creator>HOLLAND, John</creator><creator>OH, William K</creator><creator>GALSKY, Matthew D</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Use of Crowdsourcing for Cancer Clinical Trial Development</title><author>LEITER, Amanda ; SABLINSKI, Tomasz ; DIEFENBACH, Michael ; FOSTER, Marc ; GREENBERG, Alex ; HOLLAND, John ; OH, William K ; GALSKY, Matthew D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-5fb97990e20401cb886a475522cb01994df373b78aa85e470b528e3b7ffa14253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clinical trials</topic><topic>Clinical Trials as Topic - methods</topic><topic>Crowdsourcing</topic><topic>Crowdsourcing - methods</topic><topic>Feasibility</topic><topic>Feasibility Studies</topic><topic>Humans</topic><topic>Internet</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metformin - therapeutic use</topic><topic>Neoplasms - therapy</topic><topic>Patient Selection</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Protocol</topic><topic>Research Design</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEITER, Amanda</creatorcontrib><creatorcontrib>SABLINSKI, Tomasz</creatorcontrib><creatorcontrib>DIEFENBACH, Michael</creatorcontrib><creatorcontrib>FOSTER, Marc</creatorcontrib><creatorcontrib>GREENBERG, Alex</creatorcontrib><creatorcontrib>HOLLAND, John</creatorcontrib><creatorcontrib>OH, William K</creatorcontrib><creatorcontrib>GALSKY, Matthew D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEITER, Amanda</au><au>SABLINSKI, Tomasz</au><au>DIEFENBACH, Michael</au><au>FOSTER, Marc</au><au>GREENBERG, Alex</au><au>HOLLAND, John</au><au>OH, William K</au><au>GALSKY, Matthew D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Crowdsourcing for Cancer Clinical Trial Development</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>106</volume><issue>10</issue><spage>1</spage><pages>1-</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><coden>JNCIEQ</coden><abstract>Patient and physician awareness and acceptance of trials and patient ineligibility are major cancer clinical trial accrual barriers. Yet, trials are typically conceived and designed by small teams of researchers with limited patient input. We hypothesized that through crowdsourcing, the intellectual and creative capacity of a large number of researchers, clinicians, and patients could be harnessed to improve the clinical trial design process. In this study, we evaluated the feasibility and utility of using an internet-based crowdsourcing platform to inform the design of a clinical trial exploring an antidiabetic drug, metformin, in prostate cancer. Over a six-week period, crowd-sourced input was collected from 60 physicians/researchers and 42 patients/advocates leading to several major (eg, eligibility) and minor modifications to the clinical trial protocol as originally designed. Crowdsourcing clinical trial design is feasible, adds value to the protocol development process, and may ultimately improve the efficiency of trial conduct.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>25217580</pmid><doi>10.1093/jnci/dju258</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 2014-10, Vol.106 (10), p.1 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1561979989 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Antineoplastic Agents - therapeutic use Biological and medical sciences Clinical trials Clinical Trials as Topic - methods Crowdsourcing Crowdsourcing - methods Feasibility Feasibility Studies Humans Internet Male Medical sciences Metformin - therapeutic use Neoplasms - therapy Patient Selection Prostatic Neoplasms - drug therapy Protocol Research Design Tumors |
| title | Use of Crowdsourcing for Cancer Clinical Trial Development |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T21%3A43%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20Crowdsourcing%20for%20Cancer%20Clinical%20Trial%20Development&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=LEITER,%20Amanda&rft.date=2014-10-01&rft.volume=106&rft.issue=10&rft.spage=1&rft.pages=1-&rft.issn=0027-8874&rft.eissn=1460-2105&rft.coden=JNCIEQ&rft_id=info:doi/10.1093/jnci/dju258&rft_dat=%3Cproquest_cross%3E3482791431%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1620420813&rft_id=info:pmid/25217580&rfr_iscdi=true |