Effect of Doxycycline vs Placebo on Retinal Function and Diabetic Retinopathy Progression in Mild to Moderate Nonproliferative Diabetic Retinopathy: A Randomized Proof-of-Concept Clinical Trial

IMPORTANCE: Microglia have been associated with inflammatory changes underlying diabetic retinopathy. OBJECTIVE: To investigate whether low-dose oral doxycycline monohydrate, a drug capable of inhibiting microglial activation, can improve or slow the deterioration of retinal function and whether it...

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Veröffentlicht in:	JAMA ophthalmology 2014-09, Vol.132 (9), p.1137-1142
Hauptverfasser:	Scott, Ingrid U, Jackson, Gregory R, Quillen, David A, Klein, Ronald, Liao, Jason, Gardner, Thomas W
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Anti-Bacterial Agents - administration & dosage Contrast Sensitivity - physiology Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 2 - physiopathology Diabetic Retinopathy - diagnosis Diabetic Retinopathy - drug therapy Diabetic Retinopathy - physiopathology Disease Progression Double-Blind Method Doxycycline - administration & dosage Female Humans Male Microglia - drug effects Middle Aged Retinal Neurons - physiology Tomography, Optical Coherence Visual Field Tests Visual Fields - physiology
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