A sensitive and selective method for the quantitative analysis of miglitol in rat plasma using unique solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry

ABSTRACT A sensitive, selective and robust liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method was developed for the quantification of miglitol in rat plasma. The sample preparation procedures involved protein precipitation and unique solid‐phase extraction, which efficiently removed so...

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Veröffentlicht in:	Biomedical chromatography 2014-10, Vol.28 (10), p.1423-1429
Hauptverfasser:	Mizuno-Yasuhira, Akiko, Kinoshita, Kohnosuke, Jingu, Shigeji, Yamaguchi, Jun-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Deoxynojirimycin - analogs & derivatives 1-Deoxynojirimycin - blood Animals Chromatography, Liquid - methods Drug Stability LC-MS/MS Linear Models Male miglitol monomeric sugar plasma quantification Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Solid Phase Extraction - methods SPE Tandem Mass Spectrometry - methods Temperature
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