Desmoid tumors of the head and neck: A therapeutic challenge
Desmoid tumor, or aggressive fibromatosis, is a rare, histologically benign, fibroblastic lesion that infrequently presents in the head and neck. Desmoid tumors often grow locally, invasively, and may, in rare instances, be fatal secondary to invasion into critical structures, such as airway or majo...
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| Veröffentlicht in: | Head & neck 2014-10, Vol.36 (10), p.1517-1526 |
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| creator | de Bree, Eelco Zoras, Odysseas Hunt, Jennifer L. Takes, Robert P. Suárez, Carlos Mendenhall, William M. Hinni, Michael L. Rodrigo, Juan P. Shaha, Ashok R. Rinaldo, Alessandra Ferlito, Alfio de Bree, Remco |
| description | Desmoid tumor, or aggressive fibromatosis, is a rare, histologically benign, fibroblastic lesion that infrequently presents in the head and neck. Desmoid tumors often grow locally, invasively, and may, in rare instances, be fatal secondary to invasion into critical structures, such as airway or major vessels. The most common treatment is surgery, but desmoid tumors are characteristically associated with a high local recurrence rate after resection. Although the margin status seems to be of importance, operations that avoid function loss and esthetic disfigurement should be the primary goal. The efficacy of postoperative radiotherapy is controversial. Its potential benefit should be carefully balanced against possible radiation‐induced adverse effects. Alternative treatment modalities, such as primary radiotherapy and medical treatment or a wait‐and‐see policy, may be preferable to mutilating surgery. Considering all the aforementioned, it seems obvious that desmoid tumors of the head and neck present a therapeutic challenge and require an individualized approach. © 2014 Wiley Periodicals, Inc. Head Neck, 36: 1517–1526, 2014 |
| doi_str_mv | 10.1002/hed.23496 |
| format | Article |
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Desmoid tumors often grow locally, invasively, and may, in rare instances, be fatal secondary to invasion into critical structures, such as airway or major vessels. The most common treatment is surgery, but desmoid tumors are characteristically associated with a high local recurrence rate after resection. Although the margin status seems to be of importance, operations that avoid function loss and esthetic disfigurement should be the primary goal. The efficacy of postoperative radiotherapy is controversial. Its potential benefit should be carefully balanced against possible radiation‐induced adverse effects. Alternative treatment modalities, such as primary radiotherapy and medical treatment or a wait‐and‐see policy, may be preferable to mutilating surgery. Considering all the aforementioned, it seems obvious that desmoid tumors of the head and neck present a therapeutic challenge and require an individualized approach. © 2014 Wiley Periodicals, Inc. 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Desmoid tumors often grow locally, invasively, and may, in rare instances, be fatal secondary to invasion into critical structures, such as airway or major vessels. The most common treatment is surgery, but desmoid tumors are characteristically associated with a high local recurrence rate after resection. Although the margin status seems to be of importance, operations that avoid function loss and esthetic disfigurement should be the primary goal. The efficacy of postoperative radiotherapy is controversial. Its potential benefit should be carefully balanced against possible radiation‐induced adverse effects. Alternative treatment modalities, such as primary radiotherapy and medical treatment or a wait‐and‐see policy, may be preferable to mutilating surgery. Considering all the aforementioned, it seems obvious that desmoid tumors of the head and neck present a therapeutic challenge and require an individualized approach. © 2014 Wiley Periodicals, Inc. Head Neck, 36: 1517–1526, 2014</description><subject>aggressive fibromatosis</subject><subject>desmoid</subject><subject>desmoid tumor</subject><subject>Diagnosis, Differential</subject><subject>Fibromatosis, Aggressive - diagnosis</subject><subject>Fibromatosis, Aggressive - etiology</subject><subject>Fibromatosis, Aggressive - genetics</subject><subject>Fibromatosis, Aggressive - radiotherapy</subject><subject>Fibromatosis, Aggressive - surgery</subject><subject>Fibromatosis, Aggressive - therapy</subject><subject>head and neck</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - etiology</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Radiotherapy, Adjuvant</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>Watchful Waiting</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1P3DAQBmCrApWvHvoHqkhc6CFge-y4QVwQsCyIUlWigps1dibdQD62diK6_75ZluWA1JNHo2deWS9jnwU_FJzLoxkVhxJUnn1g24LnJuWgzMZyVpACN2qL7cT4yDmHTMmPbEsqJQXXcpudnFNsuqpI-qHpQky6MulnlMwIiwTbImnJPx0np8tlwDkNfeUTP8O6pvY37bHNEutIn17fXfZrcnF3Nk1vflxenZ3epF5Lk6UIWAqeCeeE0MKToAIVAjgl0IEqvM9zxVFluXMS0El0pTcGgCR906hhlx2scueh-zNQ7G1TRU91jS11Q7RCZyI33EA20v139LEbQjv-7kVBbpSCUX1dKR-6GAOVdh6qBsPCCm6XldqxUvtS6Wi_vCYOrhm3a7nucARHK_Bc1bT4f5KdXpyvI9PVRRV7-vt2geHJZgaMtve3l1ZPHr5f3_3Udgr_ALb4jOg</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>de Bree, Eelco</creator><creator>Zoras, Odysseas</creator><creator>Hunt, Jennifer L.</creator><creator>Takes, Robert P.</creator><creator>Suárez, Carlos</creator><creator>Mendenhall, William M.</creator><creator>Hinni, Michael L.</creator><creator>Rodrigo, Juan P.</creator><creator>Shaha, Ashok R.</creator><creator>Rinaldo, Alessandra</creator><creator>Ferlito, Alfio</creator><creator>de Bree, Remco</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Desmoid tumors of the head and neck: A therapeutic challenge</title><author>de Bree, Eelco ; Zoras, Odysseas ; Hunt, Jennifer L. ; Takes, Robert P. ; Suárez, Carlos ; Mendenhall, William M. ; Hinni, Michael L. ; Rodrigo, Juan P. ; Shaha, Ashok R. ; Rinaldo, Alessandra ; Ferlito, Alfio ; de Bree, Remco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5276-a3af1061bb1151ce1eda4a33b41ab34dcc9940a469bb23ab2abfc7733e2e85a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>aggressive fibromatosis</topic><topic>desmoid</topic><topic>desmoid tumor</topic><topic>Diagnosis, Differential</topic><topic>Fibromatosis, Aggressive - diagnosis</topic><topic>Fibromatosis, Aggressive - etiology</topic><topic>Fibromatosis, Aggressive - genetics</topic><topic>Fibromatosis, Aggressive - radiotherapy</topic><topic>Fibromatosis, Aggressive - surgery</topic><topic>Fibromatosis, Aggressive - therapy</topic><topic>head and neck</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - etiology</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Radiotherapy, Adjuvant</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>Watchful Waiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Bree, Eelco</creatorcontrib><creatorcontrib>Zoras, Odysseas</creatorcontrib><creatorcontrib>Hunt, Jennifer L.</creatorcontrib><creatorcontrib>Takes, Robert P.</creatorcontrib><creatorcontrib>Suárez, Carlos</creatorcontrib><creatorcontrib>Mendenhall, William M.</creatorcontrib><creatorcontrib>Hinni, Michael L.</creatorcontrib><creatorcontrib>Rodrigo, Juan P.</creatorcontrib><creatorcontrib>Shaha, Ashok R.</creatorcontrib><creatorcontrib>Rinaldo, Alessandra</creatorcontrib><creatorcontrib>Ferlito, Alfio</creatorcontrib><creatorcontrib>de Bree, Remco</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Bree, Eelco</au><au>Zoras, Odysseas</au><au>Hunt, Jennifer L.</au><au>Takes, Robert P.</au><au>Suárez, Carlos</au><au>Mendenhall, William M.</au><au>Hinni, Michael L.</au><au>Rodrigo, Juan P.</au><au>Shaha, Ashok R.</au><au>Rinaldo, Alessandra</au><au>Ferlito, Alfio</au><au>de Bree, Remco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Desmoid tumors of the head and neck: A therapeutic challenge</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2014-10</date><risdate>2014</risdate><volume>36</volume><issue>10</issue><spage>1517</spage><epage>1526</epage><pages>1517-1526</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Desmoid tumor, or aggressive fibromatosis, is a rare, histologically benign, fibroblastic lesion that infrequently presents in the head and neck. Desmoid tumors often grow locally, invasively, and may, in rare instances, be fatal secondary to invasion into critical structures, such as airway or major vessels. The most common treatment is surgery, but desmoid tumors are characteristically associated with a high local recurrence rate after resection. Although the margin status seems to be of importance, operations that avoid function loss and esthetic disfigurement should be the primary goal. The efficacy of postoperative radiotherapy is controversial. Its potential benefit should be carefully balanced against possible radiation‐induced adverse effects. Alternative treatment modalities, such as primary radiotherapy and medical treatment or a wait‐and‐see policy, may be preferable to mutilating surgery. Considering all the aforementioned, it seems obvious that desmoid tumors of the head and neck present a therapeutic challenge and require an individualized approach. © 2014 Wiley Periodicals, Inc. Head Neck, 36: 1517–1526, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24421052</pmid><doi>10.1002/hed.23496</doi><tpages>10</tpages></addata></record> |
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| subjects | aggressive fibromatosis desmoid desmoid tumor Diagnosis, Differential Fibromatosis, Aggressive - diagnosis Fibromatosis, Aggressive - etiology Fibromatosis, Aggressive - genetics Fibromatosis, Aggressive - radiotherapy Fibromatosis, Aggressive - surgery Fibromatosis, Aggressive - therapy head and neck Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - etiology Head and Neck Neoplasms - genetics Head and Neck Neoplasms - radiotherapy Head and Neck Neoplasms - surgery Head and Neck Neoplasms - therapy Humans Magnetic Resonance Imaging Radiotherapy, Adjuvant Tomography, X-Ray Computed Treatment Outcome Watchful Waiting |
| title | Desmoid tumors of the head and neck: A therapeutic challenge |
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