Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake

Abstract Salsolinol is formed non-enzymatically when ethanol-derived acetaldehyde binds to dopamine, yielding 2 distinct products, i.e., salsolinol and isosalsolinol. Early animal studies, revealing that salsolinol promotes alcohol consumption and recent evidence that animals will readily self-admin...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2014-09, Vol.48 (6), p.551-559
Hauptverfasser:	Quintanilla, María Elena, Rivera-Meza, Mario, Berrios-Cárcamo, Pablo A, Bustamante, Diego, Buscaglia, Marianne, Morales, Paola, Karahanian, Eduardo, Herrera-Marschitz, Mario, Israel, Yedy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking Animals Behavioral sensitization Biotechnology Conditioning (Psychology) Dopamine Drug dosages Ethanol intake Experiments Female Isoquinolines - pharmacokinetics Isoquinolines - pharmacology Isosalsolinol Laboratory animals Motivation - drug effects Motor Activity - drug effects Naltrexone Naltrexone - pharmacology Physiology Place preference Psychiatry Rats Rats, Wistar Rodents Salsolinol Studies Ventral Tegmental Area - drug effects Ventral Tegmental Area - physiology
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