Cytotoxic granules in distinct subsets of cutaneous lupus erythematosus
Summary In cutaneous lupus erythematosus (CLE), the pathogenetic role of cytotoxic granules has been demonstrated in the subacute and discoid subtypes, which show interface dermatitis, but little is known about tumid (T)CLE, which does not show this interface dermatitis, and evolves with minimal epi...
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| Veröffentlicht in: | Clinical and experimental dermatology 2014-10, Vol.39 (7), p.835-839 |
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| container_title | Clinical and experimental dermatology |
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| creator | Fogagnolo, L. Soares, T. C. B. Senna, C. G. Souza, E. M. Blotta, M. H. S. L. Cintra, M. L. |
| description | Summary
In cutaneous lupus erythematosus (CLE), the pathogenetic role of cytotoxic granules has been demonstrated in the subacute and discoid subtypes, which show interface dermatitis, but little is known about tumid (T)CLE, which does not show this interface dermatitis, and evolves with minimal epidermal changes. We studied cytotoxic T lymphocytes and cytotoxic granules in discoid (n = 21), subacute (n = 17), and tumid (n = 21) CLE samples. Skin sections were immunohistochemically stained for CD8, CD56, perforin, granzyme A, granzyme B, and granulysin. Inflammatory cells containing the four subtypes of cytotoxic granules were found in all the three CLE forms; however, only the TCLE group showed a positive correlation between the density of CD8+ cells and each subtype of cytotoxic granule‐positive cells. In addition, only the TCLE group showed synergy between the densities of cells containing cytotoxic granule subtypes. Cytotoxic granules are important in the pathomechanism of TCLE. They may perform functions other than apoptosis, including maintenance of inflammation and dermal mucinous deposits in TCLE. |
| doi_str_mv | 10.1111/ced.12428 |
| format | Article |
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In cutaneous lupus erythematosus (CLE), the pathogenetic role of cytotoxic granules has been demonstrated in the subacute and discoid subtypes, which show interface dermatitis, but little is known about tumid (T)CLE, which does not show this interface dermatitis, and evolves with minimal epidermal changes. We studied cytotoxic T lymphocytes and cytotoxic granules in discoid (n = 21), subacute (n = 17), and tumid (n = 21) CLE samples. Skin sections were immunohistochemically stained for CD8, CD56, perforin, granzyme A, granzyme B, and granulysin. Inflammatory cells containing the four subtypes of cytotoxic granules were found in all the three CLE forms; however, only the TCLE group showed a positive correlation between the density of CD8+ cells and each subtype of cytotoxic granule‐positive cells. In addition, only the TCLE group showed synergy between the densities of cells containing cytotoxic granule subtypes. Cytotoxic granules are important in the pathomechanism of TCLE. They may perform functions other than apoptosis, including maintenance of inflammation and dermal mucinous deposits in TCLE.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/ced.12428</identifier><identifier>PMID: 25214407</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Antigens, Differentiation, T-Lymphocyte - metabolism ; CD56 Antigen - analysis ; CD8-Positive T-Lymphocytes - immunology ; Cell Count ; Granzymes - metabolism ; Humans ; Immunohistochemistry ; Lupus Erythematosus, Cutaneous - immunology ; Lupus Erythematosus, Cutaneous - metabolism ; Lupus Erythematosus, Cutaneous - pathology ; Perforin - metabolism ; Retrospective Studies ; T-Lymphocytes, Cytotoxic - immunology</subject><ispartof>Clinical and experimental dermatology, 2014-10, Vol.39 (7), p.835-839</ispartof><rights>2014 British Association of Dermatologists</rights><rights>2014 British Association of Dermatologists.</rights><rights>Copyright © 2014 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4578-7ab2e990ef180d3e72ae4ab315a233a6a65c0e8bced003caa01f5185d056ee6a3</citedby><cites>FETCH-LOGICAL-c4578-7ab2e990ef180d3e72ae4ab315a233a6a65c0e8bced003caa01f5185d056ee6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25214407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fogagnolo, L.</creatorcontrib><creatorcontrib>Soares, T. C. B.</creatorcontrib><creatorcontrib>Senna, C. G.</creatorcontrib><creatorcontrib>Souza, E. M.</creatorcontrib><creatorcontrib>Blotta, M. H. S. L.</creatorcontrib><creatorcontrib>Cintra, M. L.</creatorcontrib><title>Cytotoxic granules in distinct subsets of cutaneous lupus erythematosus</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
In cutaneous lupus erythematosus (CLE), the pathogenetic role of cytotoxic granules has been demonstrated in the subacute and discoid subtypes, which show interface dermatitis, but little is known about tumid (T)CLE, which does not show this interface dermatitis, and evolves with minimal epidermal changes. We studied cytotoxic T lymphocytes and cytotoxic granules in discoid (n = 21), subacute (n = 17), and tumid (n = 21) CLE samples. Skin sections were immunohistochemically stained for CD8, CD56, perforin, granzyme A, granzyme B, and granulysin. Inflammatory cells containing the four subtypes of cytotoxic granules were found in all the three CLE forms; however, only the TCLE group showed a positive correlation between the density of CD8+ cells and each subtype of cytotoxic granule‐positive cells. In addition, only the TCLE group showed synergy between the densities of cells containing cytotoxic granule subtypes. Cytotoxic granules are important in the pathomechanism of TCLE. They may perform functions other than apoptosis, including maintenance of inflammation and dermal mucinous deposits in TCLE.</description><subject>Antigens, Differentiation, T-Lymphocyte - metabolism</subject><subject>CD56 Antigen - analysis</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cell Count</subject><subject>Granzymes - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lupus Erythematosus, Cutaneous - immunology</subject><subject>Lupus Erythematosus, Cutaneous - metabolism</subject><subject>Lupus Erythematosus, Cutaneous - pathology</subject><subject>Perforin - metabolism</subject><subject>Retrospective Studies</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9v1DAQxa0K1C6lB74AisQFDmnHdmzHRxTKglRaIUBUvViOd9KmZJPFf9Tut69puhyQmMOMNPrN05tHyCsKxzTXicPVMWUVq_fIgnIpSsY4PCML4KBKqXl9QF6EcAtAOVVinxwwwWhVgVqQZbONU5zue1dcezumAUPRj8WqD7EfXSxCagPGUExd4VK0I04pFEPa5I5-G29wbeMUUnhJnnd2CHj0NA_Jj4-n35tP5dnF8nPz_qx0lVB1qWzLUGvAjtaw4qiYxcq2nArLOLfSSuEA6zZ_BMCdtUA7QWuxAiERpeWH5O2su_HT74QhmnUfHA7DbM1QIamWWmuZ0Tf_oLdT8mN290hVoGvQmXo3U85PIXjszMb3a-u3hoL5k67JXsxjupl9_aSY2nXe7shdnBk4mYG7fsDt_5VMc_phJ1nOFzlwvP97Yf0vIxVXwvw8X5pLob5cXX1rzFf-ACU4kw4</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Fogagnolo, L.</creator><creator>Soares, T. C. B.</creator><creator>Senna, C. G.</creator><creator>Souza, E. M.</creator><creator>Blotta, M. H. S. L.</creator><creator>Cintra, M. L.</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Cytotoxic granules in distinct subsets of cutaneous lupus erythematosus</title><author>Fogagnolo, L. ; Soares, T. C. B. ; Senna, C. G. ; Souza, E. M. ; Blotta, M. H. S. L. ; Cintra, M. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4578-7ab2e990ef180d3e72ae4ab315a233a6a65c0e8bced003caa01f5185d056ee6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antigens, Differentiation, T-Lymphocyte - metabolism</topic><topic>CD56 Antigen - analysis</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cell Count</topic><topic>Granzymes - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lupus Erythematosus, Cutaneous - immunology</topic><topic>Lupus Erythematosus, Cutaneous - metabolism</topic><topic>Lupus Erythematosus, Cutaneous - pathology</topic><topic>Perforin - metabolism</topic><topic>Retrospective Studies</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fogagnolo, L.</creatorcontrib><creatorcontrib>Soares, T. C. B.</creatorcontrib><creatorcontrib>Senna, C. G.</creatorcontrib><creatorcontrib>Souza, E. M.</creatorcontrib><creatorcontrib>Blotta, M. H. S. L.</creatorcontrib><creatorcontrib>Cintra, M. L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fogagnolo, L.</au><au>Soares, T. C. B.</au><au>Senna, C. G.</au><au>Souza, E. M.</au><au>Blotta, M. H. S. L.</au><au>Cintra, M. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic granules in distinct subsets of cutaneous lupus erythematosus</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2014-10</date><risdate>2014</risdate><volume>39</volume><issue>7</issue><spage>835</spage><epage>839</epage><pages>835-839</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
In cutaneous lupus erythematosus (CLE), the pathogenetic role of cytotoxic granules has been demonstrated in the subacute and discoid subtypes, which show interface dermatitis, but little is known about tumid (T)CLE, which does not show this interface dermatitis, and evolves with minimal epidermal changes. We studied cytotoxic T lymphocytes and cytotoxic granules in discoid (n = 21), subacute (n = 17), and tumid (n = 21) CLE samples. Skin sections were immunohistochemically stained for CD8, CD56, perforin, granzyme A, granzyme B, and granulysin. Inflammatory cells containing the four subtypes of cytotoxic granules were found in all the three CLE forms; however, only the TCLE group showed a positive correlation between the density of CD8+ cells and each subtype of cytotoxic granule‐positive cells. In addition, only the TCLE group showed synergy between the densities of cells containing cytotoxic granule subtypes. Cytotoxic granules are important in the pathomechanism of TCLE. They may perform functions other than apoptosis, including maintenance of inflammation and dermal mucinous deposits in TCLE.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25214407</pmid><doi>10.1111/ced.12428</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Antigens, Differentiation, T-Lymphocyte - metabolism CD56 Antigen - analysis CD8-Positive T-Lymphocytes - immunology Cell Count Granzymes - metabolism Humans Immunohistochemistry Lupus Erythematosus, Cutaneous - immunology Lupus Erythematosus, Cutaneous - metabolism Lupus Erythematosus, Cutaneous - pathology Perforin - metabolism Retrospective Studies T-Lymphocytes, Cytotoxic - immunology |
| title | Cytotoxic granules in distinct subsets of cutaneous lupus erythematosus |
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