Asymmetric Cell–Matrix and Biomechanical Abnormalities in Elastin Insufficiency Induced Aortopathy

Aortopathy is characterized by vascular smooth muscle cell (VSMC) abnormalities and elastic fiber fragmentation. Elastin insufficient ( Eln +/− ) mice demonstrate latent aortopathy similar to human disease. We hypothesized that aortopathy manifests primarily in the aorto-pulmonary septal (APS) side...

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Veröffentlicht in:	Annals of biomedical engineering 2014-10, Vol.42 (10), p.2014-2028
Hauptverfasser:	Krishnamurthy, Varun K., Evans, Ashlie N., Wansapura, Janaka P., Osinska, Hanna, Maddy, Kelsey E., Biechler, Stefanie V., Narmoneva, Daria A., Goodwin, Richard L., Hinton, Robert B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Aorta - abnormalities Aorta - physiology Aortic Diseases - pathology Aortic Diseases - physiopathology Biochemistry Biological and Medical Physics Biomechanical Phenomena Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Child Classical Mechanics Elastic Modulus Elastin - deficiency Elastin - genetics Elastin - physiology Humans Mice, Transgenic Myocytes, Smooth Muscle - pathology Neural Crest - abnormalities Proteoglycans - metabolism
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